212 results found
    1. Plant Biology

    Landscape genomic prediction for restoration of a Eucalyptus foundation species under climate change

    Megan Ann Supple, Jason G Bragg ... Justin O Borevitz
    Empirical patterns of genomic and phenotypic variation across the landscape are used to develop a predictive model that will help build resilient ecological communities.
    1. Neuroscience

    Vocal development in a Waddington landscape

    Yayoi Teramoto, Daniel Y Takahashi ... Asif A Ghazanfar
    An integrated landscape framework shows how the coordinated changes in vocal apparatus, muscles, nervous system, and social interaction together influence the trajectory of vocal development.
    1. Cancer Biology

    Horizontal transfer of whole mitochondria restores tumorigenic potential in mitochondrial DNA-deficient cancer cells

    Lan-Feng Dong, Jaromira Kovarova ... Jiri Neuzil
    A genetic approach documents that mitochondrial DNA moves from donor cells to recipient mtDNA-depleted cells in whole mitochondria and that this restores mitochondrial respiration and the capacity of the cells to form tumours.
    1. Microbiology and Infectious Disease

    Host and viral determinants of airborne transmission of SARS-CoV-2 in the Syrian hamster

    Julia R Port, Dylan H Morris ... Vincent J Munster
    An experimental animal model provides further insights into the host and viral mechanisms underlying airborne transmission of SARS-CoV-2.
    1. Cancer Biology
    2. Computational and Systems Biology

    Mitochondrial respiratory gene expression is suppressed in many cancers

    Ed Reznik, Qingguo Wang ... Chris Sander
    Building on previous work (Reznik et al., 2016), independent measurements of mitochondrial genome copy number and expression indicate that several solid tumor types suppress respiratory metabolism compared to normal tissue.
    1. Developmental Biology
    2. Stem Cells and Regenerative Medicine

    Cellular reprogramming with ATOH1, GFI1, and POU4F3 implicate epigenetic changes and cell-cell signaling as obstacles to hair cell regeneration in mature mammals

    Amrita A Iyer, Ishwar Hosamani ... Andrew K Groves
    Cells of the mammalian cochlea can be reprogrammed to produce mechanosensory hair cells, but epigenetic changes in the cochlea make this process less efficient with age.
    1. Computational and Systems Biology
    2. Evolutionary Biology

    Adaptation to mutational inactivation of an essential gene converges to an accessible suboptimal fitness peak

    João V Rodrigues, Eugene I Shakhnovich
    When an essential metabolic gene in E. coli is mutationally inactivated, subsequent evolution rarely reverts the mutation to wild type but rather follows unexpected paths that rewire metabolic fluxes.
    1. Genetics and Genomics

    The genomic landscape of transposable elements in yeast hybrids is shaped by structural variation and genotype-specific modulation of transposition rate

    Mathieu Hénault, Souhir Marsit ... Christian R Landry
    The gain of transposable elements in yeast hybrids does not scale with genetic divergence levels and is most impacted by structural variations and multiple aspects of individual hybrid genetic backgrounds.
    1. Ecology

    Habitat loss weakens the positive relationship between grassland plant richness and above-ground biomass

    Yongzhi Yan, Scott Jarvie, Qing Zhang
    Habitat loss rather than fragmentation per se can weaken the positive BEF relationship by reducing the percentage of grassland specialists in the community.
    1. Biochemistry and Chemical Biology
    2. Evolutionary Biology

    Reverse evolution leads to genotypic incompatibility despite functional and active site convergence

    Miriam Kaltenbach, Colin J Jackson ... Nobuhiko Tokuriki
    Enzyme evolution is reversible on a structural and functional (phenotypic) level, but through a different mutational pathway that leads to genotypic incompatibility with the ancestor.

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