1,600 results found
  1. Peer Review

    Edited by Peter A Rodgers
    A series of articles exploring how journals, funding agencies and universities review papers, grant applications and people.
  2. Meta-research

    Meta-Research: A Collection of Articles

    Edited by Peter A Rodgers
    The study of science itself is a growing field of research.
  3. Episode 46: March 2018

    In this episode, we hear about autism, insulin resistance, Sci-Hub, coping with low levels of oxygen, and how the brain responds to blindness.
    1. Developmental Biology
    2. Neuroscience

    Glial insulin regulates cooperative or antagonistic Golden goal/Flamingo interactions during photoreceptor axon guidance

    Hiroki Takechi et al.
    Timely regulation of growth cone dynamics, including filopodial and cytoskeletal rearrangements through phosphorylation signals from glial cells, shapes the photoreceptor axon targeting.
    1. Computational and Systems Biology
    2. Neuroscience

    Discovering and deciphering relationships across disparate data modalities

    Joshua T Vogelstein et al.
    Multiscale Graph Correlation, an interpretable hypothesis test with strong theoretical guarantees for discerning relationships in complex data, requires about half the sample size as other methods, whilst maintaining computational tractability.
    1. Neuroscience

    Frequency-dependent mobilization of heterogeneous pools of synaptic vesicles shapes presynaptic plasticity

    Frédéric Doussau et al.
    The mobilization or silencing of two heterogeneous pools of synaptic vesicles via different frequencies probably enables granule cell to Purkinje cell synapses to better discriminate between the high-rate code of sensory information and background noise.
    1. Genetics and Genomics
    2. Microbiology and Infectious Disease

    Population genomics reveals the origin and asexual evolution of human infective trypanosomes

    William Weir et al.
    The protozoan parasite Trypanosoma brucei gambiense has undergone recent clonal evolution that reveals the theoretically predicted Meselson effect at a genome-wide level.
    1. Evolutionary Biology
    2. Plant Biology

    Origin and evolution of the nuclear auxin response system

    Sumanth K Mutte et al.
    The system that controls gene expression by the plant signaling molecule auxin has deep evolutionary roots, and stepwise increases in system complexity shaped the highly diverse auxin response in land plants.
    1. Cell Biology
    2. Developmental Biology

    Single-cell RNA-seq analysis reveals penaeid shrimp hemocyte subpopulations and cell differentiation process

    Keiichiro Koiwai et al.
    Single-cell mRNA sequencing on hemocytes of penaeid shrimp revealed six types of hemocytes, type markers, differentiation pathways, and different immune roles among these subpopulations based on their transcriptional profiles.
    1. Cancer Biology
    2. Chromosomes and Gene Expression

    Transcription-associated topoisomerase 2α (TOP2A) activity is a major effector of cytotoxicity induced by G-quadruplex ligands

    Madeleine Bossaert et al.
    Topoisomerase 2α DNA breaks induced by G-quadruplex ligands are associated with a topological stress resulting from a transcription-dependent mechanism and counteracted by DNA topoisomerase 1 and factors promoting transcription elongation.

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