231 results found
    1. Ecology

    A SLC4 family bicarbonate transporter is critical for intracellular pH regulation and biomineralization in sea urchin embryos

    Marian Y Hu et al.
    Cellular carbon accumulation systems are a fundamental prerequisite for biomineralization to stabilize pH and to supply inorganic carbon for CaCO3 precipitation under changing environmental conditions.
    1. Evolutionary Biology

    Oldest skeleton of a fossil flying squirrel casts new light on the phylogeny of the group

    Isaac Casanovas-Vilar et al.
    Flying squirrels may have originated earlier than previously thought and remained unchanged for almost 12 million years.
    1. Cell Biology
    2. Neuroscience

    Tenectin recruits integrin to stabilize bouton architecture and regulate vesicle release at the Drosophila neuromuscular junction

    Qi Wang et al.
    Characterization of Tnc as a selective integrin ligand at the Drosophila NMJ allows for unprecedented insights into our understanding of extracellular matrix/integrin interactions at synaptic locations and reveals novel, distinct presynaptic and postsynaptic integrin functions.
    1. Cell Biology
    2. Developmental Biology

    Rho1 activation recapitulates early gastrulation events in the ventral, but not dorsal, epithelium of Drosophila embryos

    Ashley Rich et al.
    Spatially and temporally patterned activation of the small GTPase Rho1 indicates that ventral-specific factors contribute to cell- and tissue-level behaviors during ventral furrow formation, the first step in Drosophila gastrulation.
    1. Developmental Biology
    2. Evolutionary Biology

    A novel enhancer near the Pitx1 gene influences development and evolution of pelvic appendages in vertebrates

    Abbey C Thompson et al.
    Regulatory sequences downstream of a key limb identity gene are required for normal sizes of leg bones, and are changed in wild species with dramatic alterations in pelvic structures.
    1. Cell Biology
    2. Developmental Biology

    Mechanical force regulates tendon extracellular matrix organization and tenocyte morphogenesis through TGFbeta signaling

    Arul Subramanian et al.
    Perturbation of mechanical force at muscle attachments and its effects on tendon morphogenesis provides insights into the mechanisms underlying cellular responses to tensional force and resulting extracellular matrix production.
    1. Ecology
    2. Genetics and Genomics

    Novel adverse outcome pathways revealed by chemical genetics in a developing marine fish

    Elin Sørhus et al.
    Global gene expression analysis unravels the underlying mechanisms for distinct crude oil induced defects in Atlantic haddock eggs and larvae.
    1. Genetics and Genomics
    2. Microbiology and Infectious Disease

    Whole genome comparison of a large collection of mycobacteriophages reveals a continuum of phage genetic diversity

    Welkin H Pope et al.
    A continuum of genome relationships is discovered through comparative genomics of 627 sequenced mycobacteriophages isolated and characterized in an integrated research/education initiative.
    1. Stem Cells and Regenerative Medicine

    Identification of a new stem cell population that generates Drosophila flight muscles

    Rajesh D Gunage et al.
    Large flight muscle of Drosophila are made by the regulated amplification of a newly identified stem cell population.
    1. Cell Biology
    2. Developmental Biology

    The Drosophila formin Fhos is a primary mediator of sarcomeric thin-filament array assembly

    Arkadi Shwartz et al.
    Actin is incorporated into the thin-filament arrays of skeletal muscle sarcomeres in discrete steps, and Fhos, the Drosophila homolog of FHOD-family formins, is an essential player in the process.

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