113 results found
    1. Cell Biology
    2. Developmental Biology

    The interplay of stiffness and force anisotropies drives embryo elongation

    Thanh Thi Kim Vuong-Brender, Martine Ben Amar ... Michel Labouesse
    Elongation of C. elegans embryos requires stiffness and force to be specifically oriented in a coordinated manner in different cells.
    1. Developmental Biology

    Tension-driven multi-scale self-organisation in human iPSC-derived muscle fibers

    Qiyan Mao, Achyuth Acharya ... Frank Schnorrer
    In vitro grown human muscle fibers display remarkable self-organisation capacities at the tissue, cellular, and molecular levels that are coordinated by mechanical tension.
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    A potent voltage-gated calcium channel inhibitor engineered from a nanobody targeted to auxiliary CaVβ subunits

    Travis J Morgenstern, Jinseo Park ... Henry M Colecraft
    A novel engineered protein that uncouples electrical signals from downstream biological responses in excitable cells provides a unique investigative tool with potential therapeutic applications.
    1. Physics of Living Systems

    Diameter dependence of transport through nuclear pore complex mimics studied using optical nanopores

    Nils Klughammer, Anders Barth ... Cees Dekker
    Nuclear pore complex mimics based on solid-state nanopores show significant selectivity below a diameter of 55 nm, which decreases gradually for larger pore diameters.
    1. Neuroscience

    Brain-wide mapping of neural activity controlling zebrafish exploratory locomotion

    Timothy W Dunn, Yu Mu ... Misha B Ahrens
    Whole-brain activity imaging in larval zebrafish reveals brain regions that influence patterns of spontaneous movement to increase local exploration efficiency.
    1. Cell Biology
    2. Plant Biology

    Subcellular and supracellular mechanical stress prescribes cytoskeleton behavior in Arabidopsis cotyledon pavement cells

    Arun Sampathkumar, Pawel Krupinski ... Elliot M Meyerowitz
    In the Arabidopsis epidermis, the internal mechanical stress of a cell competes with the external stress to control microtubule behavior, providing a framework to understand the mechanical feedbacks that underlie plant morphogenesis.
    1. Cancer Biology

    A hyperspectral method to assay the microphysiological fates of nanomaterials in histological samples

    Elliott D SoRelle, Orly Liba ... Adam de la Zerda
    A new technique for biodistribution and targeted uptake studies of nanoparticle imaging agents is demonstrated and used to achieve levels of detail that are inaccessible through existing methods.
    1. Epidemiology and Global Health

    Unbiased proteomics, histochemistry, and mitochondrial DNA copy number reveal better mitochondrial health in muscle of high-functioning octogenarians

    Ceereena Ubaida-Mohien, Sally Spendiff ... Russell T Hepple
    Skeletal muscle from world-class octogenarian athletes, representing a population with very high physical function in advanced age, exhibits greater mass and strength that is associated with overrepresentation of proteins involved in mitochondrial biology and more oxidatively competent muscle fibers.
    1. Cell Biology
    2. Developmental Biology

    Canonical NF-κB signaling maintains corneal epithelial integrity and prevents corneal aging via retinoic acid

    Qian Yu, Soma Biswas ... Jing Li
    Corneal aging is regulated by the NF-κB-retinoic acid pathway and can be delayed by retinoic acid administration.
    1. Cell Biology
    2. Developmental Biology

    Patterned cortical tension mediated by N-cadherin controls cell geometric order in the Drosophila eye

    Eunice HoYee Chan, Pruthvi Chavadimane Shivakumar ... Pierre-François Lenne
    N-cadherin at heterotypic contacts controls the level and asymmetric localisation of Myosin-II motor, thereby influencing cell shapes and cell packing.

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