6,066 results found
    1. Chromosomes and Gene Expression
    2. Neuroscience

    The LIM protein complex establishes a retinal circuitry of visual adaptation by regulating Pax6 α-enhancer activity

    Yeha Kim et al.
    Regulation of Pax6 expression through the α-enhancer fine-tunes amacrine cell subtype number, and consequently, the visual output of the retina.
    1. Structural Biology and Molecular Biophysics

    Decoding WW domain tandem-mediated target recognitions in tissue growth and cell polarity

    Zhijie Lin et al.
    A systematic and quantitative investigation showing how highly specific WW domain-mediated protein-protein interaction network is organized in cell growth and polarity.
    1. Microbiology and Infectious Disease

    CCL2 mobilizes ALIX to facilitate Gag-p6 mediated HIV-1 virion release

    David O Ajasin et al.
    Effect of CCL2 on HIV-1 replication is mediated by mobilization of ALIX from F-actin leading to enhanced virion release and improved fitness and this requires the Gag late motif, LYPX.
    1. Computational and Systems Biology

    Quantitative time-resolved analysis reveals intricate, differential regulation of standard- and immuno-proteasomes

    Juliane Liepe et al.
    Experimental and computational analyses reveal how proteasomal hydrolysis is regulated and show that peptide transport is the rate-limiting step and the main differentiating factor between human standard- and immuno-proteasomes.
    1. Biochemistry and Chemical Biology

    An allosteric Sec61 inhibitor traps nascent transmembrane helices at the lateral gate

    Andrew L MacKinnon et al.
    A small molecule, cotransin, blocks transmembrane domains form integrating into cell membranes by allosterically ‘locking’ the lateral gate of the Sec61 translocation channel.
    1. Developmental Biology

    HIPPO signaling resolves embryonic cell fate conflicts during establishment of pluripotency in vivo

    Tristan Frum et al.
    HIPPO signaling antagonizes the apical domain of polarized cells, driving cell internalization, regulated gene expression, and cell fate change during formation of pluripotent stem cell progenitors in the mouse embryo.
  1. Point of view: Motivating participation in open science by examining researcher incentives

    Sarah E Ali-Khan et al.
    A survey of researchers at the Montreal Neurological Institute and Hospital provides insights into the challenges and opportunities involved in adopting an open science policy across an entire patient-oriented academic institution.
    1. Cell Biology
    2. Neuroscience

    2018 Gairdner Awards: The past, present and future of light-gated ion channels and optogenetics

    Sheena A Josselyn
    Research into light-gated ion channels called channelrhodospins laid the foundations for the development of optogenetics, a technique that has gone on to revolutionize neuroscience.
  2. Peer Review: Searching for the one

    Helga Groll
    The views of peers are important when applying for a faculty position, but so are research plans and being a good 'fit'.

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