236 results found
    1. Cell Biology
    2. Neuroscience

    Sensing of nutrients by CPT1C regulates late endosome/lysosome anterograde transport and axon growth

    Marta Palomo-Guerrero et al.
    The pseudoenzyme CPT1C is able to sense changes in intracellular malonyl-CoA levels caused by nutrients or energy stress and regulate late endosomes/lysosomes anterograde transport, necessary for proper axon growth.
    1. Neuroscience

    Animal Models of Disease: Fly model causes neurological rethink

    Madhumala K Sadanandappa, Mani Ramaswami
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    1. Biochemistry and Chemical Biology

    Cell Biology: Opening up new fronts in the fight against cholesterol

    Russell A DeBose-Boyd, Jay D Horton
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    1. Biochemistry and Chemical Biology

    Cytokines: Revealing the secrets of secretion

    Antony Galione, Lianne C Davis
    An intracellular ion channel may have a central role in the release of cytokines by macrophages.
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    1. Epidemiology and Global Health
    2. Microbiology and Infectious Disease

    Science Forum: Viral factors in influenza pandemic risk assessment

    Marc Lipsitch et al.
    We identify key strengths and limitations in use of viral genotyping and phenotyping to estimate pandemic risk from influenza A viruses, focusing on 3 traits, hemagglutinin binding specificity, hemagglutinin pH of activation, and polymerase complex efficiency.
    1. Cell Biology

    Misfolded GPI-anchored proteins are escorted through the secretory pathway by ER-derived factors

    Eszter Zavodszky, Ramanujan S Hegde
    ER-resident chaperones and cargo receptors make excursions to the cell surface and endocytic compartments when they accompany misfolded clients to lysosomes for degradation.
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    Electrostatic lateral interactions drive ESCRT-III heteropolymer assembly

    Sudeep Banjade et al.
    ESCRT-III heteropolymers utilize non-specific lateral electrostatic interactions to recognize one another, which may enable the polymers to slide along one another and adapt to different curvatures.
    1. Cell Biology
    2. Ecology

    Ubiquitous macropinocytosis in anthozoans

    Philippe Ganot et al.
    Macropinocytosis, the process of non-specific endocytosis, is a major gateway for large volumes of surrounding medium and nanoparticles to coral cells.
    1. Immunology and Inflammation
    2. Microbiology and Infectious Disease

    An integrin/MFG-E8 shuttle loads HIV-1 viral-like particles onto follicular dendritic cells in mouse lymph node

    Chung Park, John H Kehrl
    Intravital imaging with HIV-1 viral-like particle in mouse model reveals a mechanism for HIV-1 uptake by subcapsular sinus macrophages that facilitates HIV-1 spreading tofollicular dendritic and B cells.
    1. Cell Biology

    Brain-specific Drp1 regulates postsynaptic endocytosis and dendrite formation independently of mitochondrial division

    Kie Itoh et al.
    Genetic and cell biological analyses reveal a new role of Drp1 in postsynaptic endocytosis during brain development beyond mitochondrial division GTPase.

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