1 result found
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    Identification of NPC1 as the target of U18666A, an inhibitor of lysosomal cholesterol export and Ebola infection

    Feiran Lu, Qiren Liang ... Michael S Brown
    A nanomolar inhibitor of cholesterol transport out of endosomes/lysosomes can be crosslinked to the “sterol-sensing domain” of NPC1, which implicates this domain in the transmembrane transport of cholesterol.

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