323 results found
    1. Genetics and Genomics

    Firefly genomes illuminate parallel origins of bioluminescence in beetles

    Timothy R Fallon et al.
    The first genomic view of beetle luciferase evolution indicates evolutionary independence of luciferase between fireflies and click-beetles, and provide valuable datasets which will accelerate the discovery of new biotechnological tools.
    1. Cell Biology
    2. Developmental Biology

    Single-cell RNA-seq analysis reveals penaeid shrimp hemocyte subpopulations and cell differentiation process

    Keiichiro Koiwai et al.
    Single-cell mRNA sequencing on hemocytes of penaeid shrimp revealed six types of hemocytes, type markers, differentiation pathways, and different immune roles among these subpopulations based on their transcriptional profiles.
    1. Cell Biology

    Splicing variation of BMP2K balances abundance of COPII assemblies and autophagic degradation in erythroid cells

    Jaroslaw Cendrowski et al.
    Erythroid-enriched BMP2K kinase, in addition to its predicted function in endocytosis, regulates distribution and abundance of COPII assemblies and autophagic degradation through opposing actions of its two splicing variants.
    1. Cell Biology
    2. Microbiology and Infectious Disease

    Tuberculosis-associated IFN-I induces Siglec-1 on tunneling nanotubes and favors HIV-1 spread in macrophages

    Maeva Dupont et al.
    Type-I interferon enriched microenvironment generated by Mycobacterium tuberculosis induces the Siglec-1 receptor expression in human macrophages, including on tunneling nanotubes, and contributes to the exacerbation of cell-to-cell transfer of HIV-1.
    1. Biochemistry and Chemical Biology

    Agonist-mediated switching of ion selectivity in TPC2 differentially promotes lysosomal function

    Susanne Gerndt et al.
    The lysosomal ion channel TPC2 emerges as an example of an ion channel in which ion selectivity is not fixed but rather agonist-selective.
    1. Cell Biology
    2. Structural Biology and Molecular Biophysics

    A structural mechanism for phosphorylation-dependent inactivation of the AP2 complex

    Edward A Partlow et al.
    Cryo-EM reveals how a protein called NECAP inactivates the AP2 clathrin adaptor complex through concerted engagement of two domains which confer specificity for membrane-activated and phosphorylated AP2.
    1. Neuroscience

    Otoferlin acts as a Ca2+ sensor for vesicle fusion and vesicle pool replenishment at auditory hair cell ribbon synapses

    Nicolas Michalski et al.
    Targeted mutations in a Ca2+-binding site of otoferlin, a transmembrane protein of synaptic vesicles defective in a recessive form of deafness, reveal its Ca2+ sensor role both for vesicle fusion and vesicle pool replenishment.
    1. Cell Biology

    Integrated control of transporter endocytosis and recycling by the arrestin-related protein Rod1 and the ubiquitin ligase Rsp5

    Michel Becuwe, Sébastien Léon
    A novel regulatory step in the endocytic pathway, which occurs post-internalization, takes place at the trans-Golgi network and involves the arrestin-related protein Rod1 and the ubiquitin ligase Rsp5.
    1. Cell Biology

    Structure of cellular ESCRT-III spirals and their relationship to HIV budding

    Anil G Cashikar et al.
    Electron microscopy on native membranes reveals the shape and potential function of protein machinery responsible for budding vesicles and viruses away from the cytoplasm.
    1. Computational and Systems Biology
    2. Developmental Biology

    The pattern of nodal morphogen signaling is shaped by co-receptor expression

    Nathan D Lord et al.
    Ligand capture by cell surface receptor complexes sets the shape of the Nodal signaling pattern in zebrafish.

Refine your results by:

Type
Research categories