2,312 results found
    1. Evolutionary Biology
    2. Epidemiology and Global Health
    3. Microbiology and Infectious Disease
    4. Genetics and Genomics

    Evolutionary Medicine: A Special Issue

    Edited by George H Perry et al.
    eLife is pleased to present a Special Issue to highlight recent advances in the growing and increasingly interdisciplinary field of evolutionary medicine.
  1. Open-source Community Call: Covid-19 open projects updates

    Watch the recording of our discussion about the recent efforts by the open-source community to review and map preprints throughout the pandemic.
    1. Cell Biology
    2. Immunology and Inflammation

    Neutrophil infiltration regulates clock-gene expression to organize daily hepatic metabolism

    María Crespo et al.
    Circadian neutrophil infiltration in the liver modulates liver clock-gene expression and daily hepatic metabolism through the secretion of elastase and activation of JNK-FGF21-Bmal1 axis in the hepatocyte.
    1. Developmental Biology

    SlitC-PlexinA1 mediates iterative inhibition for orderly passage of spinal commissural axons through the floor plate

    Hugo Ducuing et al.
    A combination of in vivo models and imaging techniques reveals the distribution of guidance cues and their mechanisms of action during commissural axon navigation of intermediate target.
    1. Computational and Systems Biology
    2. Microbiology and Infectious Disease

    Drivers and sites of diversity in the DNA adenine methylomes of 93 Mycobacterium tuberculosis complex clinical isolates

    Samuel J Modlin et al.
    Fully assembled DNA methylomes from phylogeographically diverse clinical Mycobacterium tuberculosis complex isolates reveals 'intercellular mosaic methylation' as a source of epigenetic diversity.
    1. Developmental Biology
    2. Evolutionary Biology

    Secondary ossification center induces and protects growth plate structure

    Meng Xie et al.
    The principle underlying the appearance of the growth plate, an organ responsible for longitudinal growth, has implications for various cartilage pathologies including growth abnormalities in children, trauma and osteoarthritis.
    1. Cell Biology

    Single-cell dynamics of pannexin-1-facilitated programmed ATP loss during apoptosis

    Hiromi Imamura et al.
    Cleavage of pannexin-1 channel by caspases facilitates the loss of intracellular ATP level and attenuates glycolytic metabolism of apoptotic cells.
    1. Epidemiology and Global Health
    2. Evolutionary Biology

    Investigating pleiotropic effects of statins on ischemic heart disease in the UK Biobank using Mendelian randomisation

    CM Schooling et al.
    Identifying why statins differ from other major lipid modifiers has revealed a new modifiable target of intervention for cardiovascular disease relevant to both drug development and optimal statin use.
    1. Evolutionary Biology

    Primary and promiscuous functions coexist during evolutionary innovation through whole protein domain acquisitions

    José Antonio Escudero et al.
    The coexistence of ancestral and innovative functions is possible and fosters evolutionary innovation in events involving the acquisition of whole protein domains.
    1. Neuroscience

    Different theta frameworks coexist in the rat hippocampus and are coordinated during memory-guided and novelty tasks

    Víctor J López-Madrona et al.
    Integration and segregation of information of memory and sensory in the hippocampus could be achieved by the coordination of distinct theta-gamma coding frameworks.

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