845 results found
    1. Microbiology and Infectious Disease

    TRIM28 promotes HIV-1 latency by SUMOylating CDK9 and inhibiting P-TEFb

    Xiancai Ma et al.
    TRIM28 was found to be a versatile dual-function latency contributor by bridging both suppressive epigenetic modifications and RNAP II transcriptional-pausing, and can be a novel target to develop latency-reversing agents.
    1. Microbiology and Infectious Disease

    Distinct chromatin functional states correlate with HIV latency reactivation in infected primary CD4+ T cells

    Emilie Battivelli et al.
    Analysis of HIV integration sites from induced and non-induced latently infected populations reveals the role of genomic localization and chromatin context in the fate of HIV-1 infection and the reversal of viral latency.
    1. Microbiology and Infectious Disease

    HIV-1 Latency: Coloring hidden viruses

    Marina Lusic
    An improved dual-color reporter reveals how the fate of latent HIV-1 depends on where it integrates in the human genome.
    Insight
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  1. Meta-Research: How significant are the public dimensions of faculty work in review, promotion and tenure documents?

    Juan P Alperin et al.
    An analysis of review, promotion and tenure documents from 129 US and Canadian universities suggests institutions could better fulfill their public missions by changing how they incentivize the public dimensions of faculty work.
    1. Microbiology and Infectious Disease

    Research: A comprehensive and quantitative exploration of thousands of viral genomes

    Gita Mahmoudabadi, Rob Phillips
    A compendium of critical genomic numbers for viruses through the lenses of different viral classification systems.
    1. Ecology
    2. Human Biology and Medicine

    Point of View: A transatlantic perspective on 20 emerging issues in biological engineering

    Bonnie C Wintle et al.
    Horizon scanning has been used to identify opportunities and risks presented by 20 emerging issues in the field of biological engineering.
  2. Research Culture: A survey of new PIs in the UK

    Sophie E Acton et al.
    The challenges faced by new PIs in the UK include difficulties in recruiting PhD students, maintaining a good work-life balance and securing permanent positions.
    1. Neuroscience

    Anatomical basis and physiological role of cerebrospinal fluid transport through the murine cribriform plate

    Jordan N Norwood et al.
    Chemical ablation of olfactory sensory neurons blocks cerebrospinal fluid outflow into the nasal epithelium, leading to alterations of cerebrospinal fluid dynamics.
    1. Immunology and Inflammation

    The quantity of CD40 signaling determines the differentiation of B cells into functionally distinct memory cell subsets

    Takuya Koike et al.
    Unveiling a mechanism for the fate decision of B-cell differentiation into two functionally distinct memory B cell subsets.
    1. Ecology
    2. Evolutionary Biology

    Variable opportunities for outcrossing result in hotspots of novel genetic variation in a pathogen metapopulation

    Anna-Liisa Laine et al.
    In natural pathogen populations opportunities for sexual outcrossing vary, leading to spatial variation in genetic diversity and between-season survival.

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