778 results found
    1. Microbiology and Infectious Disease

    TRIM28 promotes HIV-1 latency by SUMOylating CDK9 and inhibiting P-TEFb

    Xiancai Ma et al.
    TRIM28 was found to be a versatile dual-function latency contributor by bridging both suppressive epigenetic modifications and RNAP II transcriptional-pausing, and can be a novel target to develop latency-reversing agents.
    1. Microbiology and Infectious Disease

    Distinct chromatin functional states correlate with HIV latency reactivation in infected primary CD4+ T cells

    Emilie Battivelli et al.
    Analysis of HIV integration sites from induced and non-induced latently infected populations reveals the role of genomic localization and chromatin context in the fate of HIV-1 infection and the reversal of viral latency.
    1. Microbiology and Infectious Disease

    HIV-1 Latency: Coloring hidden viruses

    Marina Lusic
    An improved dual-color reporter reveals how the fate of latent HIV-1 depends on where it integrates in the human genome.
    Insight
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  1. Meta-Research: How significant are the public dimensions of faculty work in review, promotion and tenure documents?

    Juan P Alperin et al.
    An analysis of review, promotion and tenure documents from 129 US and Canadian universities suggests institutions could better fulfill their public missions by changing how they incentivize the public dimensions of faculty work.
    1. Microbiology and Infectious Disease

    Research: A comprehensive and quantitative exploration of thousands of viral genomes

    Gita Mahmoudabadi, Rob Phillips
    A compendium of critical genomic numbers for viruses through the lenses of different viral classification systems.
    1. Ecology
    2. Human Biology and Medicine

    Point of View: A transatlantic perspective on 20 emerging issues in biological engineering

    Bonnie C Wintle et al.
    Horizon scanning has been used to identify opportunities and risks presented by 20 emerging issues in the field of biological engineering.
    1. Stem Cells and Regenerative Medicine

    Neural stem cells induce the formation of their physical niche during organogenesis

    Ali Seleit et al.
    A physical niche for neural stem cells is generated by the induction of the immediate skin epithelium, a process triggered by the arrival of neural precursors during sensory organ formation in medaka.
    1. Developmental Biology
    2. Stem Cells and Regenerative Medicine

    Embryonic hematopoiesis modulates the inflammatory response and larval hematopoiesis in Drosophila

    Wael Bazzi et al.
    Distinct hematopoietic waves interact via transcriptional cascades specific to embryonic hemocytes to ensure the proper immune response in Drosophila.​.
    1. Neuroscience

    Uncovering temporal structure in hippocampal output patterns

    Kourosh Maboudi et al.
    Machine learning models of coordinated hippocampal ensemble activity during sharp wave ripple activity encode structure that mirrors the place cell map expressed during exploration, and enable a new paradigm for analyzing and understanding this offline activity.
    1. Developmental Biology
    2. Evolutionary Biology

    Evolutionary changes in transcription factor coding sequence quantitatively alter sensory organ development and function

    Simon Weinberger et al.
    The coding sequences of a very highly conserved family of neurogenic transcription factors from different species have evolved to generate proteins that have different life times causing them to display quantitatively different neural induction potentials.

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