Upon deletion of threonine deaminases, biosynthesis of isoleucine is rescued by two promiscuous reactions, one emerges under aerobic conditions and the other is naturally active under anaerobic conditions.
The human brain maintains a representation of latent task states within frontoparietal networks during the generalization of behaviors to novel settings.
The likelihood to perform tool use during foraging is linked to personality traits in ants, suggesting an original interplay between consistent inter-individual variability and division of labor in social species.
Oculomotor circuits are always busy planning the next eye movement, and this explains why, when a visual target appears, some eye movements toward it are produced very quickly whereas others take a long time to prepare.
Targeting the mothers, and other household members, of newborns with a mixture of respiratory syncytial virus (RSV) vaccines is both efficient and effective at reducing RSV hospitalizations.
Dorsomedial and dorsolateral striatal neural activity differ during early learning of action sequences but do not change with performance improvement across sessions, and become similar after extended training.
OptoGranules reveal the function of G3BP1 as a stress granule scaffold and demonstrate that protracted stress granule assembly is sufficient to drive neurodegeneration and the evolution of ALS-FTD pathology.
An unbiased genetic screen in human cells shows that the molecular target of a natural product with promising anticancer activity is a membrane phospholipid.
HIV-specific T cells remain detectable for years in HIV-infected individuals on antiretroviral therapy and importantly, mostly (68%) recognize HIV viruses that have the capacity to rebound following treatment interruption.
Transient DNA interactions by DNA-binding proteins are utilized by herpes simple virus as an alternative route to generate membraneless compartments in the nucleus without invoking phase separation.
