442 results found
    1. Microbiology and Infectious Disease

    Establishment and stability of the latent HIV-1 DNA reservoir

    Johanna Brodin et al.
    Building on previous work (Zanini et al, 2015), deep-sequencing is used to show that HIV persistence during suppressive antiretroviral therapy, the main hurdle for HIV cure, is due to homeostatic proliferation and longevity of infected cells rather than ongoing virus replication.
    1. Microbiology and Infectious Disease

    HIV-1 Latency: Coloring hidden viruses

    Marina Lusic
    An improved dual-color reporter reveals how the fate of latent HIV-1 depends on where it integrates in the human genome.
    Insight
    Available as:
    • HTML
    • PDF
    1. Microbiology and Infectious Disease

    Viral Latency: Down but not out

    Erin T Larragoite, Adam M Spivak
    A new study in monkeys suggests that treating HIV infection early with antiretroviral therapy reduces the number of latent viruses, but has little impact on viral reactivation when treatment stops.
    Insight
    Available as:
    • HTML
    • PDF
    1. Microbiology and Infectious Disease

    Distinct chromatin functional states correlate with HIV latency reactivation in infected primary CD4+ T cells

    Emilie Battivelli et al.
    Analysis of HIV integration sites from induced and non-induced latently infected populations reveals the role of genomic localization and chromatin context in the fate of HIV-1 infection and the reversal of viral latency.
    1. Microbiology and Infectious Disease

    Impact of a decade of successful antiretroviral therapy initiated at HIV-1 seroconversion on blood and rectal reservoirs

    Eva Malatinkova et al.
    An early start to long-term antiretroviral therapy limits the size of the HIV-1 reservoir more effectively than treatment that starts later.
    1. Microbiology and Infectious Disease

    USP49 potently stabilizes APOBEC3G protein by removing ubiquitin and inhibits HIV-1 replication

    Ting Pan et al.
    USP49 can increase A3G protein expression and enhance its anti-HIV-1 activity, which is also correlated with hypermutations and affects the HIV-1 latent reservoir.
    1. Neuroscience

    Neurogenesis: Delayed gratification in the adult brain

    Gerd Kempermann
    Some immature neurons in the cerebral cortex of mammals might wait for years before they become activated and finish their development.
    Insight
    Available as:
    • HTML
    • PDF
    1. Human Biology and Medicine
    2. Neuroscience

    Point of View: Predictive regulation and human design

    Peter Sterling
    Why does the human regulatory system, which evolution tuned for small satisfactions, now constantly demand 'more'?
  1. Point of View: Basic research at the epicenter of an epidemic

    William R Bishai
    William R Bishai, director of the KwaZulu-Natal Research Institute for Tuberculosis and HIV (K-RITH), argues that the best place to carry out research into a disease is in its midst.

Refine your results by:

Type
Research categories