3,626 results found
    1. Evolutionary Biology

    The age of Homo naledi and associated sediments in the Rising Star Cave, South Africa

    Paul HGM Dirks, Eric M Roberts ... Lee R Berger
    Independent dating techniques have established that the H. naledi fossils are between 236 and 335 thousand years old, indicating that small-brained hominins with relatively primitive body shapes co-existed with our early ancestors in Africa.
    1. Medicine
    2. Stem Cells and Regenerative Medicine

    Adult stem cell-derived complete lung organoid models emulate lung disease in COVID-19

    Courtney Tindle, MacKenzie Fuller ... Soumita Das
    An integrated stem cell-based disease modeling and computational approach demonstrates how proximal airway epithelium is critical for SARS-CoV-2 infectivity and distal alveolar cells are critical for simulating the host responses.
    1. Cell Biology

    Impaired iron recycling from erythrocytes is an early hallmark of aging

    Patryk Slusarczyk, Pratik Kumar Mandal ... Katarzyna Mleczko-Sanecka
    A decline in iron-recycling functions of the splenic red pulp macrophages early during aging is driven by iron loading and involves their damage and a loss in red blood cell clearance capacity.
    1. Neuroscience

    Specific lexico-semantic predictions are associated with unique spatial and temporal patterns of neural activity

    Lin Wang, Gina Kuperberg, Ole Jensen
    The prediction of specific words is associated with distinct spatial and temporal patterns of neural activity within the left inferior and medial temporal regions before the predicted word is presented.
    1. Cell Biology

    The number of cytokinesis nodes in mitotic fission yeast scales with cell size

    Wasim A Sayyad, Thomas D Pollard
    Fission yeasts cells have about 190 cytokinesis nodes in a broad band at the equator which scales with cell size and most but not all nodes condense into the contractile ring.
    1. Neuroscience

    Control of adaptive action selection by secondary motor cortex during flexible visual categorization

    Tian-Yi Wang, Jing Liu, Haishan Yao
    The secondary motor cortex causally contributes to flexible action selection during stimulus categorization with the representations of upcoming choice and sensory history regulated by the demand to remap stimulus–action association.
    1. Neuroscience

    Postsynaptic burst reactivation of hippocampal neurons enables associative plasticity of temporally discontiguous inputs

    Tanja Fuchsberger, Claudia Clopath ... Ole Paulsen
    Neuronal reactivation during dopamine modulation induces input-specific LTP at previously primed hippocampal synapses, suggesting a possible solution to the credit assignment problem and a mechanism for memory linking.
    1. Neuroscience

    One bout of neonatal inflammation impairs adult respiratory motor plasticity in male and female rats

    Austin D Hocker, Sarah A Beyeler ... Adrianne G Huxtable
    A single neonatal inflammatory event induces long-term impairments in two forms of adult respiratory motor plasticity, an important aspect of the control of breathing for compensation after injury or disease.
    1. Neuroscience

    Synchronized amplification of local information transmission by peripheral retinal input

    Pablo D Jadzinsky, Stephen A Baccus
    Peripheral retinal input transiently amplifies information transmission from ganglion cells, dynamically allocating the resources of neural activity to times of expected high information content.
    1. Cancer Biology

    Defining function of wild-type and three patient-specific TP53 mutations in a zebrafish model of embryonal rhabdomyosarcoma

    Jiangfei Chen, Kunal Baxi ... Myron S Ignatius
    Zebrafish are an optimal model organism to study rare TP53 mutations whose functions are not readily understood.

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