Lasso and latrophilin-1 interact across the synapse, while shed Lasso binds latrophilin-1 on distant growth cones and attracts them, providing a universal mechanism for short- and long-range axonal guidance.
Knockout of both latrophilin-2 and latrophilin-3 from Purkinje cells in mice selectively impairs parallel-fiber synapses, revealing a redundant but critical function for latrophilins at specific synapses.
Investigation of synapse development using a single neuron system illuminates how individual neurons specify connectivity with their postsynaptic partners and the central role of the synaptic organizer neurexin in this process.
An integrated approach for studying laminar organization in the developing mouse retina identifies two families of extracellular recognition proteins that mediate neuronal subtype-specific recognition.
Affinity capture of polyribosomes followed by RNAseq(ACAPSeq) is a technique that harnesses massively parallel sequencing to identify protein-protein interactions from any source from which polyribosomes can be purified.