Knockout of both latrophilin-2 and latrophilin-3 from Purkinje cells in mice selectively impairs parallel-fiber synapses, revealing a redundant but critical function for latrophilins at specific synapses.

Latrophilin-2 G protein coupling is required in axons but not target neurons for neural circuit assembly in the mouse hippocampus.

Spatial restriction of GPCR signaling at nascent synapses by adhesion complexes drives excitatory synapse formation and specificity in the hippocampus.

Lasso and latrophilin-1 interact across the synapse, while shed Lasso binds latrophilin-1 on distant growth cones and attracts them, providing a universal mechanism for short- and long-range axonal guidance.

Metabotropic mechanosensing occurs through an adhesion-type G protein-coupled receptor.

An integrated approach for studying laminar organization in the developing mouse retina identifies two families of extracellular recognition proteins that mediate neuronal subtype-specific recognition.

Signals from two different membrane proteins are combined to modulate how strongly sensory neurons respond to mechanical force.

Naturally occurring activity in the developing brain regulates mitochondrial motility such that mitochondria stop at active synapses, which is probably a fundamental process in brain wiring.

Calsyntenin-3 functions in cerebellar Purkinje neurons as a postsynaptic adhesion molecule that, unexpectedly, suppresses excitatory parallel-fiber synapse numbers but boosts inhibitory synapse numbers and thereby controls the excitatory/inhibitory balance of Purkinje neurons.

A Syt1-tdTomato transgenic mice with normal synaptic transmission is established to label synapse in situ and screen synaptogenic adhesion molecules.