7,522 results found
    1. Cancer Biology

    Limited inhibition of multiple nodes in a driver network blocks metastasis

    Ali Ekrem Yesilkanal et al.
    Low-dose treatment targeting multiple pathways of a pro-metastatic signaling network reduces the metastatic output of heterogeneous tumors while minimizing compensatory network activation.
    1. Neuroscience

    Neuronal complexity is attenuated in preclinical models of migraine and restored by HDAC6 inhibition

    Zachariah Bertels et al.
    In models of chronic migraine, neuronal complexity is diminished in head-pain processing regions but restored through HDAC6 inhibition, which increases tubulin acetylation and cytoskeletal flexibility, and CGRP receptor blockade.
    1. Biochemistry and Chemical Biology

    OPA1 deletion in brown adipose tissue improves thermoregulation and systemic metabolism via FGF21

    Renata O Pereira et al.
    Lack of OPA1 in BAT impairs its thermogenic activation and induces endoplasmic reticulum stress, while improving systemic metabolism and thermoregulation via ATF4-FGF21-dependent and -independent mechanisms.
    1. Computational and Systems Biology

    A convolutional neural network for the prediction and forward design of ribozyme-based gene-control elements

    Calvin M Schmidt, Christina D Smolke
    Machine learning has been applied to develop predictive models for designing RNA gene-control elements with targeted gene-regulatory activities.
    1. Computational and Systems Biology
    2. Neuroscience

    Trading mental effort for confidence in the metacognitive control of value-based decision-making

    Douglas G Lee, Jean Daunizeau
    Intra-individual variability in choice, response time, subjective effort, confidence, and choice-induced preference change and certainty gain is explained by a cost–benefit model of cognitive resource allocation.
    1. Cancer Biology

    Signaling levels mold the RAS mutation tropism of urethane

    Siqi Li, Christopher M Counter
    Genetic analyses reveal that the tropism towards specific Kras driver mutations during urethane carcinogenesis appears to arise from the selection of an oncogenic mutation in normal cells that imparts a narrow window of signaling conducive for tumorigenesis.
    1. Neuroscience

    GABAB receptor auxiliary subunits modulate Cav2.3-mediated release from medial habenula terminals

    Pradeep Bhandari et al.
    The direct interaction of R-type Ca2+ channel Cav2.3 and GABAB receptor auxiliary subunits in the active zone of medial habenula terminals scales synaptic strength independent of GABAB receptor activation.
    1. Epidemiology and Global Health
    2. Medicine

    Effects of an urban sanitation intervention on childhood enteric infection and diarrhea in Maputo, Mozambique: A controlled before-and-after trial

    Jackie Knee et al.
    Onsite sanitation maybe insufficient to interrupt transmission of enteric infections in high-burden urban settings, though risk of some infections may be reduced among children protected from birth.
    1. Neuroscience

    Response-based outcome predictions and confidence regulate feedback processing and learning

    Romy Frömer et al.
    Computational modeling, and empirical behavioral and EEG results show that learning relies not only on comparing current events to past experience, but integrates response-based outcome predictions and confidence.
    1. Structural Biology and Molecular Biophysics

    Allosteric communication in DNA polymerase clamp loaders relies on a critical hydrogen-bonded junction

    Subu Subramanian et al.
    Deep mutagenesis of a clamp-loader complex reveals a critical hydrogen-bonded junction that is important for allosteric communication in oligomeric AAA+ ATPases.

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