575 results found
    1. Developmental Biology
    2. Neuroscience

    Area-specific development of distinct projection neuron subclasses is regulated by postnatal epigenetic modifications

    Kawssar Harb, Elia Magrinelli ... Christian Alfano
    Lmo4 specifies two neuron subclasses in the mouse neocortex by promoting postnatal co-expression of the transcription factors Ctip2 and Satb2 via chromatin remodelling in a time and area-specific manner.
    1. Developmental Biology
    2. Neuroscience

    Pum2 and TDP-43 refine area-specific cytoarchitecture post-mitotically and modulate translation of Sox5, Bcl11b, and Rorb mRNAs in developing mouse neocortex

    Kawssar Harb, Melanie Richter ... Kent Duncan
    RNA-binding proteins use both translational activation and repression of key molecular determinants to post-mitotically sculpt the identity and connectivity of developing mouse neocortex in an area-specific manner.
    1. Neuroscience

    Scn1a-GFP transgenic mouse revealed Nav1.1 expression in neocortical pyramidal tract projection neurons

    Tetsushi Yamagata, Ikuo Ogiwara ... Kazuhiro Yamakawa
    In neocortex, Nav1.1 is expressed in neocortical pyramidal tract projection neurons and a minor subpopulation of cortico-cortical projection neurons in addition to its predominant expression in inhibitory neurons, while the majority of cortico-thalamic, cortico-striatal, and cortico-cortical neurons express Nav1.2.
    1. Neuroscience

    Somatotopic organization among parallel sensory pathways that promote a grooming sequence in Drosophila

    Katharina Eichler, Stefanie Hampel ... Andrew M Seeds
    A synaptic resolution somatotopic map of nearly all mechanosensory neurons on the Drosophila head that individually elicit aimed grooming of specific head locations and collectively elicit a head grooming sequence.
    1. Neuroscience

    Accelerating with FlyBrainLab the discovery of the functional logic of the Drosophila brain in the connectomic and synaptomic era

    Aurel A Lazar, Tingkai Liu ... Yiyin Zhou
    FlyBrainLab is an open-source computing platform that integrates 3D exploration and visualization of diverse Drosophila connectomic/synaptomic datasets with interactive exploration of the functional logic of modeled executable brain circuits.
    1. Developmental Biology
    2. Neuroscience

    Cellular birthdate predicts laminar and regional cholinergic projection topography in the forebrain

    Kathryn C Allaway, William Muñoz ... Gordon Fishell
    Cholinergic populations with distinct cellular birthdates innervate deep versus superficial layers of the cortex with exquisite specificity.
    1. Neuroscience

    Insula to mPFC reciprocal connectivity differentially underlies novel taste neophobic response and learning in mice

    Haneen Kayyal, Sailendrakumar Kolatt Chandran ... Kobi Rosenblum
    aIC to mPFC connections are correlative and necessary both for taste novelty behavior and learning while the reciprocal connection from mPFC to aIC is correlative and necessary for novelty behavior.
    1. Neuroscience

    Shared rhythmic subcortical GABAergic input to the entorhinal cortex and presubiculum

    Tim James Viney, Minas Salib ... Peter Somogyi
    GABAergic parvalbumin-expressing 'orchid cells' of the medial septum selectively target GABAergic neurons in connected extra-hippocampal areas of the mouse, providing rhythmically bursting inhibitory input at the peak of hippocampal 5-12 Hz theta oscillatory cycles.
    1. Neuroscience

    Heterosynaptic plasticity of the visuo-auditory projection requires cholecystokinin released from entorhinal cortex afferents

    Wenjian Sun, Haohao Wu ... Jufang He
    Visuo-auditory associative memories in the neocortex are formed through cholecystokinin-mediated heterosynaptic plasticity, primarily involving entorhinal cortex projections to the auditory cortex, highlighting intricate neural dynamics in multisensory memory processing.
    1. Neuroscience

    Gamma rhythms and visual information in mouse V1 specifically modulated by somatostatin+ neurons in reticular thalamus

    Mahmood S Hoseini, Bryan Higashikubo ... Jeanne T Paz
    Gamma rhythms and representation of visual information in the primary visual cortex are specifically modulated by somatostatin+ but not parvalbumin+ neurons in reticular thalamic nucleus.

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