46 results found
    1. Immunology and Inflammation

    CARD14E138A signalling in keratinocytes induces TNF-dependent skin and systemic inflammation

    Joan Manils et al.
    Expression of a psoriasis-associated CARD14E138A mutant in keratinocytes induces TNF-dependent localised skin and systemic inflammation independently of the adaptive immune system.
    1. Structural Biology and Molecular Biophysics

    Polyunsaturated fatty acid analogues differentially affect cardiac NaV, CaV, and KV channels through unique mechanisms

    Briana M Bohannon et al.
    Polyunsaturated fatty acid analogues show selectivity for different cardiac ion channels, suggesting their potential use for the treatment of different subtypes of Long QT Syndrome.
    1. Epidemiology and Global Health
    2. Plant Biology

    Evolutionary transitions between beneficial and phytopathogenic Rhodococcus challenge disease management

    Elizabeth A Savory et al.
    The horizontal acquisition of virulence plasmids is potentiated by production practices in plant nurseries and is sufficient to transition Rhodococcus from being beneficial to being pathogenic.
    1. Developmental Biology
    2. Medicine

    RAB23 coordinates early osteogenesis by repressing FGF10-pERK1/2 and GLI1

    Md Rakibul Hasan et al.
    RAB23 regulates calvarial bone and suture development both independently through, and by cross-talk between, Hedgehog and fibroblast growth factor signaling.
    1. Plant Biology

    Shade-induced nuclear localization of PIF7 is regulated by phosphorylation and 14-3-3 proteins in Arabidopsis

    Xu Huang et al.
    A phosphorylation dependent translocation of PIF7 and involvement of 14-3-3 proteins reveal novel regulation mechanisms in shade signal transduction.
    1. Epidemiology and Global Health
    2. Plant Biology

    Plant Pathology: Plasmid-powered evolutionary transitions

    Ryan A Melnyk, Cara H Haney
    The acquisition of a virulence plasmid is sufficient to turn a beneficial strain of Rhodococcus bacteria into a pathogen.
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    1. Cell Biology
    2. Developmental Biology

    Islet vascularization is regulated by primary endothelial cilia via VEGF-A-dependent signaling

    Yan Xiong et al.
    Primary cilia on endothelial cells are required for VEGF-A/ VEGFR2-dependent signaling, islet vascularization and, consequently, nutrient delivery and insulin disposal.
    1. Neuroscience

    Mapping the transcriptional diversity of genetically and anatomically defined cell populations in the mouse brain

    Ken Sugino et al.
    A transcriptome dataset of nearly 200 genetically identified mouse neuronal cell types revealed that short low-noise homeobox transcription factors and long neuronal effector genes best distinguish neuronal cell types.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Structures reveal opening of the store-operated calcium channel Orai

    Xiaowei Hou et al.
    The structure of the calcium channel Orai in an open conformation reveals a dilated pore and gives insight into mechanisms of ion permeation and calcium selectivity.

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