577 results found
    1. Structural Biology and Molecular Biophysics

    A critical residue in the α1M2–M3 linker regulating mammalian GABAA receptor pore gating by diazepam

    Joseph W Nors et al.
    The role of an important gating domain in linkage between the benzodiazepine drug-binding site and the pore gate in GABAA receptors.
    1. Neuroscience

    Coupling between fast and slow oscillator circuits in Cancer borealis is temperature-compensated

    Daniel Powell et al.
    The mechanism that couples two rhythmic circuits is maintained over a large temperature range although both circuits are temperature-sensitive.
    1. Neuroscience

    Laminar-specific cortico-cortical loops in mouse visual cortex

    Hedi Young et al.
    Ascending and descending cortico-cortical inputs are stronger on projection neurons that project back to the source of the inputs, forming selective interareal loops in deep but not superficial cortical layers.
    1. Neuroscience
    2. Stem Cells and Regenerative Medicine

    Dyshomeostatic modulation of Ca2+-activated K+ channels in a human neuronal model of KCNQ2 encephalopathy

    Dina Simkin et al.
    An inducedpluripotent stem cell (iPSC)-based model of KCNQ2-associated developmental epileptic encephalopathy suggests that disease is driven by dyshomeostaic neuronal mechanisms that are downstream of loss of M-current.
    1. Microbiology and Infectious Disease
    2. Structural Biology and Molecular Biophysics

    Malaria parasites use a soluble RhopH complex for erythrocyte invasion and an integral form for nutrient uptake

    Marc A Schureck et al.
    A high-resolution structure reveals how the RhopH complex traffics within Plasmodium-infected human erythrocytes to serve divergent, essential functions.
    1. Cell Biology

    ATP activation of peritubular cells drives testicular sperm transport

    David Fleck et al.
    Purinergic signaling controls mammalian sperm transport.
    1. Computational and Systems Biology

    Drift and termination of spiral waves in optogenetically modified cardiac tissue at sub-threshold illumination

    Sayedeh Hussaini et al.
    Excitability gradients in heart tissue, imposed by structured sub-threshold optogenetic stimulation, induce drift and termination of spiral waves, thus providing an explanation for successful optogenetic defibrillation in small animal hearts.
    1. Neuroscience

    Data-driven reduction of dendritic morphologies with preserved dendro-somatic responses

    Willem AM Wybo et al.
    A flexible and accurate methodology to fit reduced compartmental models to dendritic morphologies shows that models with very few compartments can capture many dendritic computations.
    1. Neuroscience

    Release probability increases towards distal dendrites boosting high-frequency signal transfer in the rodent hippocampus

    Thomas P Jensen et al.
    Excitatory synapses that occur further away from the postsynaptic cell soma exhibit greater neurotransmitter release probability, which appears to improve signal transfer fidelity for high-frequency afferent firing.
    1. Structural Biology and Molecular Biophysics

    ATP and large signaling metabolites flux through caspase-activated Pannexin 1 channels

    Adishesh K Narahari et al.
    Purified Pannexin 1 channels activated by caspase cleavage in proteoliposomes reconstitute a permeation pathway for intercellular signaling molecules important in inflammation and cell clearance.

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