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    1. Computational and Systems Biology
    2. Structural Biology and Molecular Biophysics

    Bayesian inference of kinetic schemes for ion channels by Kalman filtering

    Jan L Münch, Fabian Paul ... Klaus Benndorf
    For analyzing time-dependent patch-clamp or patch-clamp fluorometry data of ion channels in terms of Markovian models, the superiority of Bayesian filtering with respect to traditional deterministic approaches is demonstrated enabling more reliable quantification of the parameters.
    1. Structural Biology and Molecular Biophysics

    An integrated machine learning approach delineates an entropic expansion mechanism for the binding of a small molecule to α-synuclein

    Sneha Menon, Subinoy Adhikari, Jagannath Mondal
    Interaction of small molecule expands the conformational ensemble of alpha synuclein.
    1. Epidemiology and Global Health

    Coverage and system efficiencies of insecticide-treated nets in Africa from 2000 to 2017

    Samir Bhatt, Daniel J Weiss ... Peter W Gething
    Insecticide-treated net requirements for Africa have been underestimated, but mitigating for inefficiencies in net distributions can produce a cost effective path to universal coverage.
    1. Neuroscience

    Optimal compensation for neuron loss

    David GT Barrett, Sophie Denève, Christian K Machens
    Spiking networks compensate the loss of neurons instantaneously, when restoration of excitatory/inhibitory balance becomes equivalent to restoration of functionality.
    1. Genetics and Genomics

    Determining the genetic basis of anthracycline-cardiotoxicity by molecular response QTL mapping in induced cardiomyocytes

    David A Knowles, Courtney K Burrows ... Yoav Gilad
    Genetic variants that modulate transcriptomic response to doxorubicin in human iPSC-derived cardiomyocytes are predictive of cardiac damage and in vivo sensitivity to anthracycline cardiotoxicity.
    1. Evolutionary Biology
    2. Microbiology and Infectious Disease

    Integrating genotypes and phenotypes improves long-term forecasts of seasonal influenza A/H3N2 evolution

    John Huddleston, John R Barnes ... Trevor Bedford
    The combination of phenotypic measures of antigenic drift and genotypic measures of functional constraint improves the accuracy of long-term seasonal influenza A/H3N2 forecasts.
    1. Neuroscience

    Simultaneous brain, brainstem, and spinal cord pharmacological-fMRI reveals involvement of an endogenous opioid network in attentional analgesia

    Valeria Oliva, Ron Hartley-Davies ... Jonathan CW Brooks
    Attention-grabbing tasks produce rapid opioid-mediated analgesia via the descending pain modulation network to alter spinal neuronal activity.
    1. Structural Biology and Molecular Biophysics

    Accelerated cryo-EM structure determination with parallelisation using GPUs in RELION-2

    Dari Kimanius, Björn O Forsberg ... Erik Lindahl
    Using GPUs for the costly computations in cryo-EM enables structure determination in mere days on a single workstation.
    1. Developmental Biology
    2. Physics of Living Systems

    Deep learning for rapid analysis of cell divisions in vivo during epithelial morphogenesis and repair

    Jake Turley, Isaac V Chenchiah ... Helen Weavers
    Deep Learning Artificial Intelligence tools can be developed to accurately identify cell divisions during development and wound repair of epithelial tissue.
    1. Neuroscience

    A central role for the retrosplenial cortex in de novo environmental learning

    Stephen D Auger, Peter Zeidman, Eleanor A Maguire
    Functional brain imaging of subjects while travelling through an alien virtual world reveals how brain regions encode novel environments from scratch thus enabling navigation.