372 results found
    1. Developmental Biology

    Gdf3 is required for robust Nodal signaling during germ layer formation and left-right patterning

    Jose L Pelliccia et al.
    Genetic analyses demonstrate that Gdf3/Vg1 is a maternal effect gene required for robust Nodal signaling during different phases of embryogenesis including germ-layer formation, Kupffer's vesicle morphogenesis, and left-right patterning.
    1. Developmental Biology

    Patterning and Axis Formation: Heterodimers reign in the embryo

    Benjamin Tajer, Mary C Mullins
    Experiments by three independent groups on zebrafish have clarified the role of two signaling factors, Nodal and Gdf3, during the early stages of development.
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    1. Developmental Biology

    A predictive model of asymmetric morphogenesis from 3D reconstructions of mouse heart looping dynamics

    Jean-François Le Garrec et al.
    A precise sequence of left-right asymmetries, combined with mechanical constraints, is sufficient to drive the looped morphogenesis of the embryonic heart tube, with potential impact for congenital heart defects.
    1. Developmental Biology

    Heart Morphogenesis: Twists and turns

    Emily S Noël, Jeroen Bakkers
    Computational modelling of the heart tube during development reveals the interplay between tissue asymmetry and growth that helps our hearts take shape.
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    1. Developmental Biology

    The Natural History of Model Organisms: An organismal perspective on C. intestinalis development, origins and diversification

    Matthew J Kourakis, William C Smith
    The life cycle and morphology of the sea squirt Ciona intestinalis shed light on vertebrate evolution.
    1. Developmental Biology

    Addressing the ethical issues raised by synthetic human entities with embryo-like features

    John Aach et al.
    Guidelines governing research into embryos need to be updated in a way that reflects the moral status of synthetic human entities generated using the methods of synthetic biology.
    1. Neuroscience

    Biophysics of object segmentation in a collision-detecting neuron

    Richard Burkett Dewell, Fabrizio Gabbiani
    Active dendritic processing enables an individual neuron to discriminate the spatial pattern of synaptic inputs, increasing neural and behavioral selectivity for escaping an impending threat.
    1. Neuroscience

    Functional limb muscle innervation prior to cholinergic transmitter specification during early metamorphosis in Xenopus

    Francois M Lambert et al.
    Molecular labeling, electrophysiology and calcium imaging have revealed a novel switching of neurotransmitter at the frog neuromuscular junction where motoneurons transiently release glutamate before acetylcholine at synapses on developing hindlimb muscles at the onset of metamorphosis.
    1. Developmental Biology
    2. Evolutionary Biology

    Germ layer-specific regulation of cell polarity and adhesion gives insight into the evolution of mesoderm

    Miguel Salinas-Saavedra et al.
    The expression of 'bilaterian-mesodermal’ genes changes the epithelial properties of the endomesoderm during the embryogenesis of the cnidarian Nematostella vectensis.

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