1,699 results found
    1. Developmental Biology
    2. Neuroscience

    Genetic specification of left–right asymmetry in the diaphragm muscles and their motor innervation

    Camille Charoy, Sarah Dinvaut ... Valerie Castellani
    Analysis of embryonic mouse diaphragm reveals muscle and nerve left–right asymmetries set by a Nodal-dependent genetic cascade, which imprints different molecular signatures to left and right motoneurons that shape their innervation pattern.
    1. Physics of Living Systems

    Active torque generation by the actomyosin cell cortex drives left–right symmetry breaking

    Sundar Ram Naganathan, Sebastian Fürthauer ... Stephan W Grill
    The actomyosin cytoskeleton generates active chiral torques that lead to left-right asymmetry in C. elegans embryos.
    1. Developmental Biology

    Chiral cell sliding drives left-right asymmetric organ twisting

    Mikiko Inaki, Ryo Hatori ... Hisao Honda
    Left-right asymmetric rotation of the Drosophila hindgut is driven by "cell sliding," a novel cellular behavior induced by chiral cell deformation, in which cells change their position relative to subjacent neighbors as sliding directionally.
    1. Neuroscience

    Left-right side-specific endocrine signaling complements neural pathways to mediate acute asymmetric effects of brain injury

    Nikolay Lukoyanov, Hiroyuki Watanabe ... Georgy Bakalkin
    In addition to the well-established involvement of descending neural tracts, the left-right side-specific endocrine mechanism may contribute to signaling from injured brain to spinal motor circuits.
    1. Physics of Living Systems

    Fluid extraction from the left-right organizer uncovers mechanical properties needed for symmetry breaking

    Pedro Sampaio, Sara Pestana ... Susana Santos Lopes
    Zebrafish have a physiological time-window of 1 hr for breaking left-right symmetry and are highly sensitive to the left-right organizer anterior fluid mechanics rather than to the nature of its fluid content.
    1. Developmental Biology

    TEADs, Yap, Taz, Vgll4s transcription factors control the establishment of Left-Right asymmetry in zebrafish

    Jonathan Fillatre, Jean-Daniel Fauny ... Bernard Thisse
    Transcription factors downstream of Hippo signaling control formation of the Left-Right Organizer by regulating major signaling pathways, expression of transcription factors and regulators of epigenetic programming involved in this process.
    1. Developmental Biology

    Distinct myocardial lineages break atrial symmetry during cardiogenesis in zebrafish

    Almary Guerra, Raoul FV Germano ... Sven Reischauer
    A discovery of two previously unknown, molecularly distinct fields of cardiac progenitors in zebrafish provides evidence for cardiac laterality prior to the emergence of cardiac septation and allows novel insights into cardiac development and disease.
    1. Developmental Biology
    2. Neuroscience

    Sox1a mediates the ability of the parapineal to impart habenular left-right asymmetry

    Ingrid Lekk, Véronique Duboc ... Stephen W Wilson
    The sox1a gene is required for a small group on neurons on the left side of the brain to influence the generation and left-sided character of their future synaptic partners.
    1. Neuroscience

    The right hippocampus leads the bilateral integration of gamma-parsed lateralized information

    Nuria Benito, Gonzalo Martín-Vázquez ... Oscar Herreras
    High-resolution electrode recordings reveal left-right asymmetry in hippocampal gamma waves.
    1. Neuroscience

    The CNS connectome of a tadpole larva of Ciona intestinalis (L.) highlights sidedness in the brain of a chordate sibling

    Kerrianne Ryan, Zhiyuan Lu, Ian A Meinertzhagen
    Serial-section EM analysis uncovers the CNS connectome of a Ciona larva, the second of any entire nervous system, and exposes left-right asymmetries in its synaptic circuits.

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