Phillip A Erice, Xinyan Huang ... Antony Rodriguez
Mirlet7 functions as a molecular brake of CD8+IL17a+ T cells (Tc17) inflammation and chronic obstructive pulmonary disease via direct regulation RAR-related orphan receptor gamma t (RORγt).
Coordinate control of lysosomal v-ATPase subunits and biogenesis factor TFEB by miR-1 identifies a key regulatory axis with strong links to age-related proteotoxic disease.
microRNAs can serve as a surveillance system to repress nonsense mRNAs by recognizing miRNA-responsive elements in the open reading frame region downstream of the premature termination codon.
Vax1 suppresses dopaminergic neuron phenotype by inhibiting Pax6 expression in the subventricular zone of the lateral ventricle and is necessary to generate Calbindin interneurons for the postnatal olfactory bulb.
Kevin M Elias, Wojciech Fendler ... Dipanjan Chowdhury
Application of machine learning to serum miRNA profiles generated through next generation sequencing identifies a biologically relevant miRNA signature which can be deployed as a qPCR test to assist the diagnosis of epithelial ovarian cancer.
Many experimentally identified microRNA-binding sites are ineffective at mediating repression, and an improved quantitative model for predicting the effective sites is as informative as high-throughput experimental approaches.
A novel lncRNA (Ephemeron) is connected to known post-transcriptional and epigenetic regulators as part of an integrated machinery, which controls the timely exit from the naïve state of mouse embryonic stem cells.
The transcriptional activation of the key developmental timer gene, microRNA lin-4, is driven by the transmembrane transcription factor MYRF following its temporally regulated self-cleavage at the cell membrane.
