Unbiased analyses highlight context-specific crosstalk between Notch, DNA damage response genes, and PP2A, and provide a roadmap for understanding how Notch induces squamous cell differentiation.

TMEM79 targets frizzled receptor for degradation through inhibiting USP8 and is required for Xenopus embryogenesis.

Deposition of mutant oncohistones by alternative nucleosome assembly pathways results in dramatic local differences in histone methylation in pediatric diffuse midline gliomas.

This review serves as a gateway to experimental, conceptual, and quantitative themes of cytoplasmic incompatibility (CI) and outlines significant gaps in the understanding of CI's mechanism that are ripe for investigation.

Phosphatidylinositol 3-phosphate interacts with PfHsp70-1 and stabilizes the Plasmodium digestive vacuole under febrile temperatures.

C53 bridges selective autophagy with ribosome-associated quality control at the endoplasmic reticulum.

The glucose-sensing transcription factor MondoA regulates zebrafish epiboly via cholesterol biosynthesis genes including the human disease gene Nsdhl, revealing an unknown role for metabolic glucose signalling in vertebrate development.

The dependence of Nematostella germ cell specification on zygotic Hedgehog pathway activity supports the hypothesis that the eumetazoan common ancestor segregated its germline by inductive signals rather than maternal determinants.

Neuronal neurofascin takes a surprisingly circuitous route in the neuronal plasma membrane to the axon initial segment where it stabilises ion channel complexes responsible for initiating action potentials.

Pathogenesis in Spinocerebellar Ataxia Type 3 is enhanced by the heat-shock protein family member, Hsc70-4, uncovering new mechanisms of toxicity for this disease and suggesting pleiotropic roles for chaperones.