433 results found
    1. Cancer Biology
    Reproducibility Project

    Reproducibility Project: Cancer Biology

    Edited by Roger J Davis et al.
    Investigating reproducibility in preclinical cancer research.
    1. Cell Biology

    Single cell transcriptomics identifies a unique adipose lineage cell population that regulates bone marrow environment

    Leilei Zhong et al.
    A newly identified adipose lineage cell population, MALP, regulates marrow vasculature and osteogenesis in bone.
    1. Evolutionary Biology
    2. Microbiology and Infectious Disease

    Retrocopying expands the functional repertoire of APOBEC3 antiviral proteins in primates

    Lei Yang et al.
    Genomes take advantage of the gene-duplicating ability of retroelements to birth novel innate immune defense genes.
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    Astrin-SKAP complex reconstitution reveals its kinetochore interaction with microtubule-bound Ndc80

    David M Kern et al.
    Biochemical and cell biological analyses reveal that the Astrin-SKAP complex acts to stabilize kinetochore-microtubule interactions through its intrinsic microtubule binding activity and its association with the Ndc80 complex, the core component of the kinetochore-microtubule interface.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Eukaryotic translation initiation factor 3 plays distinct roles at the mRNA entry and exit channels of the ribosomal preinitiation complex

    Colin Echeverría Aitken et al.
    Eukaryotic translation initiation factor 3 (eIF3) is required to stabilize the binding of mRNA at the exit channel of the small ribosomal subunit and acts at the entry channel to accelerate mRNA recruitment to the translation preinitiation complex.
    1. Chromosomes and Gene Expression

    Nucleosomes impede Cas9 access to DNA in vivo and in vitro

    Max A Horlbeck et al.
    Nucleosomes provide a direct and profound block to the activity of the CRISPR effector protein Cas9, suggesting future sophisticated design rules for CRISPR targeting.
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    Small molecule proteostasis regulators that reprogram the ER to reduce extracellular protein aggregation

    Lars Plate et al.
    Small molecule proteostasis regulators that activate the unfolded protein response transcription factor ATF6 reduce the secretion of amyloid disease-associated proteins.
    1. Cancer Biology
    2. Physics of Living Systems

    Dissecting the immunosuppressive tumor microenvironments in Glioblastoma-on-a-Chip for optimized PD-1 immunotherapy

    Xin Cui et al.
    A biomimetic and patient-specific Glioblastoma-on-a-Chip microphysiological system provides an avenue for personalized screening of PD-1 immunotherapy and novel combinational therapies that maximize therapeutic outcomes in Glioblastoma patients.
    1. Cancer Biology
    2. Human Biology and Medicine

    The identification of dual protective agents against cisplatin-induced oto- and nephrotoxicity using the zebrafish model

    Jaime N Wertman et al.
    L-mimosine and dopamine protect against cisplatin-induced oto- and nephrotoxicity in zebrafish and human cell line models.
    1. Cell Biology
    2. Medicine

    Senotherapeutic drugs for human intervertebral disc degeneration and low back pain

    Hosni Cherif et al.
    Targeting senescent cells in human intervertebral discs, using senotherapeutics, provides a potential therapeutic strategy to prevent or reduce disc degeneration and pain.

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