364 results found
    1. Cancer Biology
    Reproducibility Project

    Reproducibility Project: Cancer Biology

    Edited by Roger J Davis et al.
    Investigating reproducibility in preclinical cancer research.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Eukaryotic translation initiation factor 3 plays distinct roles at the mRNA entry and exit channels of the ribosomal preinitiation complex

    Colin Echeverría Aitken et al.
    Eukaryotic translation initiation factor 3 (eIF3) is required to stabilize the binding of mRNA at the exit channel of the small ribosomal subunit and acts at the entry channel to accelerate mRNA recruitment to the translation preinitiation complex.
    1. Chromosomes and Gene Expression

    Nucleosomes impede Cas9 access to DNA in vivo and in vitro

    Max A Horlbeck et al.
    Nucleosomes provide a direct and profound block to the activity of the CRISPR effector protein Cas9, suggesting future sophisticated design rules for CRISPR targeting.
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    Small molecule proteostasis regulators that reprogram the ER to reduce extracellular protein aggregation

    Lars Plate et al.
    Small molecule proteostasis regulators that activate the unfolded protein response transcription factor ATF6 reduce the secretion of amyloid disease-associated proteins.
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    Astrin-SKAP complex reconstitution reveals its kinetochore interaction with microtubule-bound Ndc80

    David M Kern et al.
    Biochemical and cell biological analyses reveal that the Astrin-SKAP complex acts to stabilize kinetochore-microtubule interactions through its intrinsic microtubule binding activity and its association with the Ndc80 complex, the core component of the kinetochore-microtubule interface.
    1. Stem Cells and Regenerative Medicine

    Prospective identification of functionally distinct stem cells and neurosphere-initiating cells in adult mouse forebrain

    John K Mich et al.
    Flow cytometric isolation and fate mapping shows that neurosphere-initiating cells are highly mitotically active and persist only transiently in vivo, and are distinct from quiescent, long-lived neural stem cells.
    1. Cell Biology
    2. Developmental Biology

    Activation of PTHrP-cAMP-CREB1 signaling following p53 loss is essential for osteosarcoma initiation and maintenance

    Mannu K Walia et al.
    The loss of p53 in bone cells activates critical signaling pathways; these are also essential in bone cancer.
    1. Human Biology and Medicine
    2. Immunology and Inflammation

    Domain-swapped T cell receptors improve the safety of TCR gene therapy

    Michael T Bethune et al.
    Engineered T cell receptors enable targeted immunotherapy with a reduced risk of harmful autoimmunity.
    1. Chromosomes and Gene Expression
    2. Neuroscience

    Developmental programming modulates olfactory behavior in C. elegans via endogenous RNAi pathways

    Jennie R Sims et al.
    The OSM-9 TRPV channel is differentially regulated due to developmental programming via modulation by TGF-β signaling, endogenous RNAi and chromatin remodeling pathways.
    1. Cancer Biology
    2. Cell Biology

    TP53 exon-6 truncating mutations produce separation of function isoforms with pro-tumorigenic functions

    Nitin H Shirole et al.
    Genetic and molecular analysis of TP53 exon-6 truncating mutations reveal that these mutations, contrary to current belief, promote tumorigenesis and point towards strategies for treating cancers driven by these prevalent mutations.

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