Blood flow-driven shear forces guide the sequential signaling of two antagonistic paired receptors, a critical bi-facet step that first supports leukocyte docking, then initiates transmigration through endothelium.
Comparative transcriptomics of whole blood can be used to evaluate the systemic host response and its concordance between human and mouse malaria and aid the selection of appropriate models for translational malaria research.
Laura Medina-Ruiz, Robin Bartolini ... Gerard J Graham
The use of multi-chemokine receptor reporter mice helps to unravel the dynamics of receptor involvement in leukocyte migration in vivo and suggests specificity, rather than redundancy, in receptor use.
Cell biology analysis demonstrated for the first time the effect of chronic ethanol consumption in neutrophil impaired migration by CXCR2 downregulation and neutrophil function during acute Aspergillus fumigatus infection.
Gabriela C Olivera, Emily C Ross ... Antonio Barragan
The invasion of Toxoplasma to the CNS across cortical capillaries is restricted by the integrity of the blood-brain barrier (BBB) and exacerbated by the inflammatory response.
In the injured sciatic nerve, blood-derived monocytes and macrophages eat dying leukocytes, thereby contributing to nerve debridement and inflammation resolution, and this correlates with neuronal regeneration.
Francesco Andreata, Marc Clément ... Giuseppina Caligiuri
CD31 plays a pivotal role in neutrophil migration to inflamed sites by localizing to the uropod and promoting effective actin/integrin polarization and detachment, shedding light on the molecular mechanisms underlying extravasation and inflammation response.
The anti-cancer or lifespan extension properties of a novel genetically engineered hematopoietic blood system could be transferred horizontally in mice, which suggests a new direction of biomedical research for anti-aging/antidisease.
