809 results found
    1. Chromosomes and Gene Expression
    2. Structural Biology and Molecular Biophysics

    Archaeal chromatin ‘slinkies’ are inherently dynamic complexes with deflected DNA wrapping pathways

    Samuel Bowerman et al.
    Archaeal histones compact DNA into nucleosome-like particles of varying sizes that contort sporadically and reorient DNA wrapping.
    1. Chromosomes and Gene Expression
    2. Evolutionary Biology

    The DNA-binding protein HTa from Thermoplasma acidophilum is an archaeal histone analog

    Antoine Hocher et al.
    In Thermoplasma acidophilum, an archaeon without histones, a DNA-binding protein acquired from bacteria via horizontal gene transfer mediates histone-like chromatin architecture.
    1. Structural Biology and Molecular Biophysics

    Importin-9 wraps around the H2A-H2B core to act as nuclear importer and histone chaperone

    Abhilash Padavannil et al.
    In an unusual complex that is not dissociated by RanGTP alone, Importin-9 sequesters the H2A-H2B core from promiscuous interactions.
    1. Developmental Biology
    2. Immunology and Inflammation

    Linker histone H1.2 and H1.4 affect the neutrophil lineage determination

    Gabriel Sollberger et al.
    Linker histones affect the lineage determination of granulocyte precursor cells via regulation of the transcription factor GATA-2.
    1. Chromosomes and Gene Expression
    2. Microbiology and Infectious Disease

    ATRX promotes maintenance of herpes simplex virus heterochromatin during chromatin stress

    Joseph M Cabral et al.
    Epigenetic restriction of herpes simplex virus occurs in a biphasic manner, in which ATRX maintains viral heterochromatin after an initial phase of chromatin deposition.
    1. Biochemistry and Chemical Biology
    2. Chromosomes and Gene Expression

    ATP-dependent chromatin assembly is functionally distinct from chromatin remodeling

    Sharon E Torigoe et al.
    The Chd1 motor protein performs two functionally distinct ATP-dependent activities, nucleosome assembly and chromatin remodeling, to generate periodic arrays of nucleosomes.
    1. Chromosomes and Gene Expression
    2. Developmental Biology

    SET-9 and SET-26 are H3K4me3 readers and play critical roles in germline development and longevity

    Wenke Wang et al.
    Two SET-domain containing proteins regulate H3K4me3 by their binding to H3K4me3 through their PHD domain and directly regulate expression of a subset of genes.
    1. Chromosomes and Gene Expression
    2. Structural Biology and Molecular Biophysics

    The conformation of the histone H3 tail inhibits association of the BPTF PHD finger with the nucleosome

    Emma A Morrison et al.
    The BPTF PHD finger is inhibited from binding the methylated H3 tails in the context of the nucleosome due to their robust interaction with the nucleosomal DNA, which can be modulated by additional histone PTMs.
    1. Stem Cells and Regenerative Medicine
    2. Chromosomes and Gene Expression

    Hdac6 regulates Tip60-p400 function in stem cells

    Poshen B Chen et al.
    A normally cytoplasmic deacetylase, Hdac6, localizes to the nucleus in embryonic stem cells, where it regulates the essential Tip60-p400 chromatin remodeling complex.
    1. Biochemistry and Chemical Biology

    Identification of ‘erasers’ for lysine crotonylated histone marks using a chemical proteomics approach

    Xiucong Bao et al.
    Sirt3 functions as decrotonylase to regulate histone crotonylation dynamics.

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