1,337 results found
    1. Computational and Systems Biology
    2. Neuroscience

    Time preferences are reliable across time-horizons and verbal versus experiential tasks

    Evgeniya Lukinova, Yuyue Wang ... Jeffrey C Erlich
    People have stable time-preferences regardless of whether they are measured using a non-verbal experiential task, as is typical in animal experiments, or using a more traditional verbal task.
    1. Neuroscience

    Sleep-dependent upscaled excitability, saturated neuroplasticity, and modulated cognition in the human brain

    Mohammad Ali Salehinejad, Elham Ghanavati ... Michael A Nitsche
    The sleep-deprived brain in humans undergoes upscaled intracortical excitability which diminishes induction of LTP-like plasticity via transcranial electrical stimulation while converting the LTD-like to LTP-like plasticity and these physiological changes couple with impaired learning, memory, and attention at behavioral level.
    1. Developmental Biology

    aPKC-mediated displacement and actomyosin-mediated retention polarize Miranda in Drosophila neuroblasts

    Matthew Robert Hannaford, Anne Ramat ... Jens Januschke
    The actomyosin network and phospho-regulation combine to polarize fate determinants at the Drosophila neuroblast cell cortex.
    1. Neuroscience

    Conditional and unconditional components of aversively motivated freezing, flight and darting in mice

    Jeremy M Trott, Ann N Hoffman ... Michael S Fanselow
    When conducting fear conditioning in mice, cue-elicited activity bursts are primarily a result of nonassociative processes, and freezing behavior remains the best index for associative learning.
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    TGF-β uses a novel mode of receptor activation to phosphorylate SMAD1/5 and induce epithelial-to-mesenchymal transition

    Anassuya Ramachandran, Pedro Vizán ... Caroline S Hill
    SMAD1/5 signaling is essential for the full transforming growth factor β (TGF-β)-induced transcriptional program and physiological responses and is induced via a novel receptor activation mechanism, involving two distinct type I receptors.
    1. Chromosomes and Gene Expression
    2. Plant Biology

    Natural variation in autumn expression is the major adaptive determinant distinguishing Arabidopsis FLC haplotypes

    Jo Hepworth, Rea L Antoniou-Kourounioti ... Caroline Dean
    Variation in autumnal expression from starting expression levels and initial cold-down-regulation, rather than epigenetic silencing, is the major field variable conferred by worldwide haplotypes of the floral repressor gene, FLC.
    1. Epidemiology and Global Health
    2. Microbiology and Infectious Disease

    Plasmodium falciparum K13 mutations in Africa and Asia impact artemisinin resistance and parasite fitness

    Barbara H Stokes, Satish K Dhingra ... David A Fidock
    Plasmodium falciparum K13 mutations confer resistance to the antimalarial artemisinin in Asian and African parasites, with most gene-edited mutant K13 African parasite lines showing a fitness cost that may predict slow dissemination of artemisinin resistance in high-transmission settings.
    1. Neuroscience

    Functional brain alterations following mild-to-moderate sensorineural hearing loss in children

    Axelle Calcus, Outi Tuomainen ... Lorna F Halliday
    Mild-to-moderate sensorineural hearing loss causes changes in the neurophysiological functioning that emerge during adolescence, as suggested by both cross-sectional and longitudinal designs.
    1. Computational and Systems Biology
    2. Neuroscience

    Neuroimaging and behavioral evidence that violent video games exert no negative effect on human empathy for pain and emotional reactivity to violence

    Lukas Leopold Lengersdorff, Isabella C Wagner ... Claus Lamm
    After playing violent video games for 7 hr over the course of 2 weeks, human male participants show neither signs of decreased empathy for the pain of another person nor of decreased responsivity to violent images.
    1. Computational and Systems Biology
    2. Neuroscience

    A computational account of why more valuable goals seem to require more effortful actions

    Emmanuelle Bioud, Corentin Tasu, Mathias Pessiglione
    Behavioural evidence and computational analyses suggest that people tend to decline the pursuit of more rewarded goals because they, wrongly, expect them to require more effortful actions.

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