5,471 results found
    1. Neuroscience

    Independent and interacting value systems for reward and information in the human brain

    Irene Cogliati Dezza, Axel Cleeremans, William H Alexander
    Reward and information are independently optimized in the human prefrontal cortex, while their signals combine in subcortical regions.
    1. Stem Cells and Regenerative Medicine

    Stress responsive miR-31 is a major modulator of mouse intestinal stem cells during regeneration and tumorigenesis

    Yuhua Tian, Xianghui Ma ... Zhengquan Yu
    miR-31 drives proliferation of intestinal stem cells, and protects intestinal stem cells against apoptosis both during homeostasis and regeneration in response to ionizing radiation injury, and promotes intestinal tumorigenesis through regulation of multiple signaling pathways.
    1. Epidemiology and Global Health
    2. Genetics and Genomics

    Disease consequences of higher adiposity uncoupled from its adverse metabolic effects using Mendelian randomisation

    Susan Martin, Jessica Tyrrell ... Hanieh Yaghootkar
    Using genetics, it is possible to uncouple higher adiposity from its adverse metabolic effects and show that some obesity-associated conditions may benefit from treating the metabolic effects alone, whilst others may benefit more from weight loss.
    1. Neuroscience

    Sigma oscillations protect or reinstate motor memory depending on their temporal coordination with slow waves

    Judith Nicolas, Bradley R King ... Genevieve Albouy
    Sigma oscillations have a dual role in motor memory consolidation depending on their temporal coordination with slow waves during post-learning sleep.
    1. Neuroscience

    Minimally dependent activity subspaces for working memory and motor preparation in the lateral prefrontal cortex

    Cheng Tang, Roger Herikstad ... Shih-Cheng Yen
    The evidence of subspace computation in the lateral prefrontal cortex provides insights into the neural mechanisms underlying cognitive flexibility and interference between different cognitive processes.
    1. Neuroscience

    Variance predicts salience in central sensory processing

    Ann M Hermundstad, John J Briguglio ... Gašper Tkačik
    Psychophysical measures of human sensitivity to visual patterns reveal that the brain preferentially processes those features of stimuli that are more variable in the natural world.
    1. Microbiology and Infectious Disease

    The intricate relationship of G-Quadruplexes and bacterial pathogenicity islands

    Bo Lyu, Qisheng Song
    Unveiling the intricate web of interactions between G4 structures and pathogenicity islands in 89 bacterial genomes significantly advances our understanding of bacterial virulence mechanisms.
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    1. Neuroscience

    The cellular architecture of memory modules in Drosophila supports stochastic input integration

    Omar A Hafez, Benjamin Escribano ... Jan Pielage
    Computational modeling of a central decision neuron of Drosophila reveals an electrotonically compact architecture that is ideally suited to support efficient memory storage within a stochastically connected memory circuit.
    1. Developmental Biology

    Met and Cxcr4 cooperate to protect skeletal muscle stem cells against inflammation-induced damage during regeneration

    Ines Lahmann, Joscha Griger ... Carmen Birchmeier
    Met and Cxcr4 signaling protects muscle stem cells from the noxious environment during acute inflammation.
    1. Computational and Systems Biology
    2. Neuroscience

    Decoding contextual influences on auditory perception from primary auditory cortex

    Bernhard Englitz, Sahar Akram ... Shihab Shamma
    The perception of ambiguous steps in relative tone height is predicted by direction-selective cells in the auditory cortex, rather than the brain's represented distance between the tone heights.

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