223 results found
    1. Chromosomes and Gene Expression
    2. Genetics and Genomics

    CRISPR-mediated genetic interaction profiling identifies RNA binding proteins controlling metazoan fitness

    Adam D Norris, Xicotencatl Gracida, John A Calarco
    Synthetic genetic analysis in C. elegans identifies pairs of RNA binding protein genes that play a critical role in organism health and development.
    1. Evolutionary Biology

    Late-life fitness gains and reproductive death in Cardiocondyla obscurior ants

    Luisa Maria Jaimes-Nino, Jürgen Heinze, Jan Oettler
    Lifelong continuous reproduction, late-life investment into female sexuals, a short phase of senescence, and reproductive death characterize the life history of Cardiocondyla obscurior ant queens.
    1. Cell Biology

    Adiponectin preserves metabolic fitness during aging

    Na Li, Shangang Zhao ... Philipp E Scherer
    Adiponectin is an essential regulator for healthspan and is indispensable for sustaining a normal lifespan.
    1. Evolutionary Biology
    2. Genetics and Genomics

    Intra-species differences in population size shape life history and genome evolution

    David Willemsen, Rongfeng Cui ... Dario Riccardo Valenzano
    Population genetics in turquoise killifish wild populations reveals how small population size and genetic drift determine the accumulation of deleterious gene variants leading to short lifespan.
    1. Biochemistry and Chemical Biology

    Changes in ferrous iron and glutathione promote ferroptosis and frailty in aging Caenorhabditis elegans

    Nicole L Jenkins, Simon A James ... Gawain McColl
    As worms age reduced glutathione together with increased ferrous iron increases frailty and leads to ferroptosis, which is amenable to therapeutic intervention.
    1. Ecology
    2. Epidemiology and Global Health

    Personality links with lifespan in chimpanzees

    Drew M Altschul, William D Hopkins ... Alexander Weiss
    Among captive chimpanzees, higher agreeableness males and higher openness females survive longer.
    1. Evolutionary Biology

    A scenario for an evolutionary selection of ageing

    Tristan Roget, Claire Macmurray ... Michael Rera
    Ageing is broadly accepted as a by-product of evolution, as thus, models allowing to conceive ageing as an adaptive force of evolution could show significant importance at a time of biogerontology mostly aiming at curing ageing.
    1. Cell Biology

    Metformin extends C. elegans lifespan through lysosomal pathway

    Jie Chen, Yuhui Ou ... Ying Liu
    Metformin extends C. elegans lifespan through lysosome-dependent coordination of TORC1 and AMPK pathways.
    1. Cell Biology
    2. Chromosomes and Gene Expression

    Reduced expression of C/EBPβ-LIP extends health and lifespan in mice

    Christine Müller, Laura M Zidek ... Cornelis F Calkhoven
    Reduced expression of a single transcription factor is sufficient to improve fitness and health at old age and increases the lifespan in female mice.
    1. Genetics and Genomics

    Diversification of the Caenorhabditis heat shock response by Helitron transposable elements

    Jacob M Garrigues, Brian V Tsu ... Amy E Pasquinelli
    Helitron transposable elements, by providing high density transcription factor binding sites upstream of host genes, have diversified the heat shock response within and among Caenorhabditis species.

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