A novel single-objective light-sheet microscope with unparalleled spatiotemporal resolution enables imaging and optical manipulation of diverse biological specimens and processes.

The integration of a novel high spatiotemporal resolution volume imaging technique and a fast 3D tracking system allows capturing whole brain neural activities in a freely behaving larval zebrafish.

A new technique for biodistribution and targeted uptake studies of nanoparticle imaging agents is demonstrated and used to achieve levels of detail that are inaccessible through existing methods.

Three-dimensional fluorescence imaging of microbial eukaryotes in environmental samples allows accurate automated taxonomic profiling and quantitative data about ultrastructures and interactions of organisms.

Epithelial tissue remodeling during Drosophila embryonic development is quantitatively described by a simple law relating myosin activity and cell flow.

Growing upwards in the young seedling is controlled by two cooperative mechanical mechanisms: cellulose orientation in inner tissues and differential elasticity in epidermal cells.

Advances in quantitative phase and polarized light microscopy, combined with deep learning, reveal the architecture of human brain tissue.

Spot-On is an easy-to-use website that makes a rigorous and bias-corrected modeling framework for analysis of single-molecule tracking experiments available to all.

The poor reporting of imaging methods in the scientific literature is hindering the evaluation and replication of biomedical research.

Hydrogen-deuterium exchange, electron microscopy, and vesicle reconstitution show how binding of the autophagy adaptor NDP52 to the FIP200 subunit of the ULK1 complex triggers membrane binding in autophagy.