A cargo recognition α-helix was identified in Nup358, which is required for activation of a dynein-dependent transport pathway that is essential for brain development.
Ashley L Arthur, Amy Crawford ... Margaret A Titus
Filopodia formation requires recruitment and activation of myosin through generation of parallel, bundled actin filaments by VASP polymerase, revealing coupling between motor activation and organization of a local actin network.
Michael Puljung, Natascia Vedovato ... Frances Ashcroft
A combined FRET- and electrophysiology-based approach is used to study ATP/ADP ADP binding to the stimulatory nucleotide binding site of ATP-sensitive K+ channels and investigate their activation mechanism.
Although intermediate filaments are not widely known to contribute to the morphogenesis of cellular protusions, keratin filaments and cytolinkers are critical for the development of microridge protrusions in zebrafish skin.
Hyung-Seok Kim, Judith Neugebauer ... Jan L Christian
Endogenous BMP2/7 and BMP4/7 heterodimers form in vivo, and are the predominant functional ligand in many, if not all, tissues of developing mouse embryos.
Light absorption by the algal transcription factor Aureochrome 1a causes dimerization at the light-oxygen-voltage (LOV) sensing domain, which has implications for the design of synthetic photoreceptors for optogenetics.
Gisela Rangel-Yescas, Cecilia Cervantes ... Leon D Islas
Proton channels are present in reef-building corals and constitute important molecular players that should help understand calcification and the response of these organisms to ocean acidification.
Tarah Elizabeth Trebino, Borna Markusic ... Zhihong Wang
An in-depth binding profile analysis of BRAF domains related to RAF activation and autoinhibition unveils the distinctive roles of each domain in selecting preferred RAS isoforms and facilitating autoinhibition.
