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    1. Neuroscience

    Balancing safety and efficiency in human decision making

    Pranav Mahajan, Shuangyi Tong ... Ben Seymour
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Solid
    1. Neuroscience

    Two long-axis dimensions of hippocampal-cortical integration support memory function across the adult lifespan

    Kristin Nordin, Robin Pedersen ... Alireza Salami
    Revised
    Reviewed Preprint v2
    Updated
    • Fundamental
    • Convincing
    1. Neuroscience

    Bed nucleus of the stria terminalis regulates fear to unpredictable threat signals

    Travis D Goode, Reed L Ressler ... Stephen Maren
    The bed nucleus of the stria terminalis (BNST) is required for the expression of defensive behavior to uncertain threats, a function that is central to pathological anxiety.
    1. Genetics and Genomics
    2. Neuroscience

    Corticohippocampal circuit dysfunction in a mouse model of Dravet syndrome

    Joanna Mattis, Ala Somarowthu ... Ethan M Goldberg
    Electrophysiology, optogenetics, and imaging in a mouse model of Dravet syndrome reveals dentate gyrus circuit dysfunction driven by hyperexcitability of the perforant path input from entorhinal cortex that can be modulated by recruitment of parvalbumin-expressing inhibitory interneurons.
    1. Neuroscience

    Ventral tegmental area interneurons revisited: GABA and glutamate projection neurons make local synapses

    Lucie Oriol, Melody Chao ... Thomas S Hnasko
    Revised
    Reviewed Preprint v2
    Updated
    • Important
    • Convincing
    1. Neuroscience

    Combined transcriptomic, connectivity, and activity profiling of the medial amygdala using highly amplified multiplexed in situ hybridization (hamFISH)

    Mathew D Edwards, Ziwei Yin ... Yoh Isogai
    Not revised
    Reviewed Preprint v1
    • Important
    • Convincing
    1. Neuroscience

    Amygdala-ventral striatum circuit activation decreases long-term fear

    Susana S Correia, Anna G McGrath ... Ki A Goosens
    Behavior- or optogenetic-driven activation of a basolateral amygdala projection to the nucleus accumbens enhances infralimbic cortex activity and long-term fear extinction.
    1. Neuroscience

    Effects of nicotine compared to placebo gum on sensitivity to pain and mediating effects of peak alpha frequency

    Samantha K. Millard, Alan K.I. Chiang ... David A. Seminowicz
    Not revised
    Reviewed Preprint v1
    • Useful
    • Incomplete
    1. Neuroscience

    Seizures, behavioral deficits, and adverse drug responses in two new genetic mouse models of HCN1 epileptic encephalopathy

    Andrea Merseburg, Jacquelin Kasemir ... Bina Santoro
    Two genetic mouse models for HCN1-linked developmental epileptic encephalopathy display distinct biophysical changes in HCN1 ion channel properties but similar worsening of seizures in response to antiepileptic drugs, thereby recapitulating key features of the human disease.
    1. Computational and Systems Biology
    2. Neuroscience

    Rats exhibit similar biases in foraging and intertemporal choice tasks

    Gary A Kane, Aaron M Bornstein ... Jonathan D Cohen
    In both foraging and intertemporal choice tasks, rats prefer immediate rewards to delayed rewards, and this preference can be explained by a form of hyperbolic discounting.
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