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    1. Neuroscience

    An open cortico-basal ganglia loop allows limbic control over motor output via the nigrothalamic pathway

    Sho Aoki, Jared B Smith ... Xin Jin
    A novel connection from ventral striatum to motor cortex enables emotion and motivation to influence action and motor control.
    1. Neuroscience

    Multi-centre analysis of networks and genes modulated by hypothalamic stimulation in patients with aggressive behaviours

    Flavia Venetucci Gouveia, Jurgen Germann ... Clement Hamani
    Integrated imaging analysis of a large multi-center dataset showed that treatment of refractory aggressive behavior with hypothalamic deep brain stimulation is highly effective with specific clinical and neuroimaging features associated with treatment success.
    1. Neuroscience

    Respiration aligns perception with neural excitability

    Daniel S Kluger, Elio Balestrieri ... Joachim Gross
    Noninvasive human magnetoencephalography recordings characterize the functional relationship between respiration, neural oscillations, and performance in low-level perception.
    1. Neuroscience

    Microstructural organization of human insula is linked to its macrofunctional circuitry and predicts cognitive control

    Vinod Menon, Guillermo Gallardo ... Demian Wassermann
    In vivo quantitative analysis of multi-shell diffusion MRI reveals novel insights into microstructure of human insular cortex and its functional circuits associated with the salience network and cognitive control.
    1. Neuroscience

    Loss of cortical control over the descending pain modulatory system determines the development of the neuropathic pain state in rats

    Robert AR Drake, Kenneth A Steel ... Anthony E Pickering
    Alterations to brain network communication leading to a progressive loss in descending inhibitory modulation of the spinal cord is a key determinate of pain state development following peripheral nerve injury.
    1. Neuroscience

    Distinct representation of cue-outcome association by D1 and D2 neurons in the ventral striatum’s olfactory tubercle

    Nuné Martiros, Vikrant Kapoor ... Venkatesh N Murthy
    Real-time imaging of neural activity in behaving mice reveals that the two canonical types of neurons in the olfactory tubercle carry distinct information about learned odor cues, with D1 neurons representing stimulus valence and D2 neurons mainly representing stimulus identity.
    1. Neuroscience

    Early life stress causes sex-specific changes in adult fronto-limbic connectivity that differentially drive learning

    Jordon D White, Tanzil M Arefin ... Arie Kaffman
    Mice exposed to complex early adversity show similar diffusion MRI changes to those reported in humans and sex-specific changes in connectivity that differentially affect contextual deficits in males and females.
    1. Neuroscience

    A comprehensive excitatory input map of the striatum reveals novel functional organization

    Barbara J Hunnicutt, Bart C Jongbloets ... Tianyi Mao
    The first comprehensive map of all excitatory inputs to the mouse striatum is presented and used to define and demarcate striatal subdivisions, including a previous unappreciated novel subdivision in the posterior striatum.
    1. Neuroscience

    Primate homologs of mouse cortico-striatal circuits

    Joshua Henk Balsters, Valerio Zerbi ... Rogier B Mars
    Connectivity fingerprint matching bridges the gap between mouse and primate neuroanatomy, addressing crucial questions surrounding brain evolution that likely impact translation across species.
    1. Computational and Systems Biology

    Sex, strain, and lateral differences in brain cytoarchitecture across a large mouse population

    David Elkind, Hannah Hochgerner ... Amit Zeisel
    Across individuals of a mouse population, brain regions volumes scaled to accommodate the same amount of cells, but left hemisphere cortical regions were denser than right, and several regions of the limbic system were more pronounced in either sex.