3,831 results found
    1. Cell Biology
    2. Developmental Biology

    Cell lineage and cell cycling analyses of the 4d micromere using live imaging in the marine annelid Platynereis dumerilii

    B Duygu Özpolat et al.
    Lineage tracing at single-cell resolution reveals the presence of mesoteloblasts, the embryonic origin of mesodermal growth zone cells, and diverse cell cycling patterns of these lineages in the 'Polychaete' annelid Platynereis.
    1. Developmental Biology
    2. Stem Cells and Regenerative Medicine

    Stem cell topography splits growth and homeostatic functions in the fish gill

    Julian Stolper et al.
    The fish gill, an ever-growing organ with fast turnover rate, displays dedicated stem-cell populations for growth and homeostasis that are interchangeable upon external challenges.
    1. Developmental Biology
    2. Stem Cells and Regenerative Medicine

    Resolving stem and progenitor cells in the adult mouse incisor through gene co-expression analysis

    Kerstin Seidel et al.
    Gene co-expression analysis identifies coherent transcriptional patterns driven by distinct cell types in the mouse incisor, and functional studies of candidate genes reveal how the tissues are maintained through stem cell-fueled renewal.
    1. Epidemiology and Global Health
    2. Microbiology and Infectious Disease

    Eighteenth century Yersinia pestis genomes reveal the long-term persistence of an historical plague focus

    Kirsten I Bos et al.
    The analysis of 18th century Y. pestis genomes reveals a bacterial lineage that might be responsible for the 400-year period of European plague epidemics from the Renaissance through early modern times.
    1. Cell Biology
    2. Computational and Systems Biology

    Intrinsically disordered linkers determine the interplay between phase separation and gelation in multivalent proteins

    Tyler S Harmon et al.
    Computational modeling and theoretical analysis reveal how disordered linkers determine whether linear multivalent proteins undergo gelation with or without phase separation.
    1. Cell Biology
    2. Computational and Systems Biology

    Signaling pathways as linear transmitters

    Harry Nunns, Lea Goentoro
    Mathematical and experimental analyses suggest that despite their complex architectures, multiple metazoan signaling pathways act in physiological contexts as linear signal transmitters.
    1. Cell Biology
    2. Computational and Systems Biology

    Single-cell expression profiling reveals dynamic flux of cardiac stromal, vascular and immune cells in health and injury

    Nona Farbehi et al.
    Comprehensive scRNA-seq analysis of cardiac stromal cells in healthy and injured hearts reveals novel cell types and non-linear cell dynamics, providing new insights into cardiac inflammation, fibrosis and repair.
    1. Cell Biology
    2. Developmental Biology

    Discovery of novel determinants of endothelial lineage using chimeric heterokaryons

    Wing Tak Wong et al.
    Bioinformatic analysis of gene expression in chimeric heterokaryons can identify novel regulators of cell lineage.
    1. Evolutionary Biology
    2. Microbiology and Infectious Disease

    The contrasting phylodynamics of human influenza B viruses

    Dhanasekaran Vijaykrishna et al.
    The analysis of the genomes of two lineages of influenza B virus (Victoria and Yamagata) reveal that their phylodynamics are fundamentally different, and are determined by a complex relationship between virus transmission, age of infection and receptor binding preference.
    1. Developmental Biology

    Primed Track, high-fidelity lineage tracing in mouse pre-implantation embryos using primed conversion of photoconvertible proteins

    Maaike Welling et al.
    Primed Track is an image analysis tool that allows for computational correction of drifting specimen to enable accurate lineage tracing of mammalian pre-implantation development even for larger imaging time intervals.

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