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  1. Episode 3: August 2013

    Episode 3: August 2013

    In this episode we hear about the cocktail party effect, the role of psuedogene RNA in the immune response, the genetic origins of a common form of blindness, the flu vaccine, and the origins of schistosomiasis.
    1. Ecology
    2. Microbiology and Infectious Disease

    Endangered wild salmon infected by newly discovered viruses

    Gideon J Mordecai et al.
    Newly discovered viruses in dead and dying farmed Chinook salmon are widely distributed in threatened wild Chinook and sockeye salmon populations.
    1. Biochemistry and Chemical Biology

    An explanation for origin unwinding in eukaryotes

    Lance D Langston, Michael E O'Donnell
    CMG helicase translocates with force while encircling duplex DNA, enabling two opposing CMG complexes at an origin to melt the duplex and switch to encircling separate single strands.
    1. Cell Biology

    A critical role of VMP1 in lipoprotein secretion

    Hideaki Morishita et al.
    The ER transmembrane protein VMP1 is important for release of lipoproteins from the ER membrane into the ER lumen for secretion.
    1. Ecology
    2. Evolutionary Biology

    Signal categorization by foraging animals depends on ecological diversity

    David William Kikuchi et al.
    In richer, more even communities, foragers form broad categories among their food resources that can select for convergence among signals, including mimetic resemblances.
    1. Neuroscience

    Optogenetically induced low-frequency correlations impair perception

    Anirvan Nandy et al.
    Low-frequency correlations among neurons in monkey visual area V4 impair the animal's ability to perform an attention-demanding task, suggesting a causal role of these fluctuations in perception.
    1. Epidemiology and Global Health

    Opportunities for improved surveillance and control of dengue from age-specific case data

    Isabel Rodriguez-Barraquer et al.
    Age-specific incidence data, combined with mechanistic models of immunity, provides a unique opportunity to characterize disease transmission of dengue and other immunizing diseases at high temporal and spatial resolution.
    1. Neuroscience

    A virtual burrow assay for head–fixed mice measures habituation, discrimination, exploration and avoidance without training

    Andrew JP Fink et al.
    A naturalistic assay for head-fixed mice permits observation of a diverse set of innate and learned behaviors without requiring any training.
    1. Chromosomes and Gene Expression
    2. Genetics and Genomics

    Transcriptional adaptation in Caenorhabditis elegans

    Vahan Serobyan et al.
    Genes implicated in mutant mRNA decay and small RNA maturation and transport into the nucleus are required for transcriptional adaptation in C. elegans.
    1. Neuroscience

    Uncovering the functional anatomy of the human insula during speech

    Oscar Woolnough et al.
    Direct insular recordings in humans reveal that contrary to several prominent models of speech production, it is not engaged in pre-articulatory planning, but in auditory and somatosensory components of speech.