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    1. Plant Biology

    Natural variation in salt-induced changes in root:shoot ratio reveals SR3G as a negative regulator of root suberization and salt resilience in Arabidopsis

    Maryam Rahmati Ishka, Hayley Sussman ... Magdalena M Julkowska
    Revised
    Reviewed Preprint v2
    Updated
    • Valuable
    • Solid
    1. Chromosomes and Gene Expression
    2. Microbiology and Infectious Disease

    Human cytomegalovirus infection coopts chromatin organization to diminish TEAD1 transcription factor activity

    Khund Sayeed, Sreeja Parameswaran ... Matthew T Weirauch
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Solid
    1. Genetics and Genomics

    An ancient competition for the conserved branchpoint sequence influences physiological and evolutionary outcomes in splicing

    Karen Larissa Pereira de Castro, Jose M Abril ... W Samuel Fagg
    Not revised
    Reviewed Preprint v1
    • Important
    • Convincing
    1. Cell Biology
    2. Stem Cells and Regenerative Medicine

    Arp2/3 complex activity enables nuclear YAP for naïve pluripotency of human embryonic stem cells

    Nathaniel Paul Meyer, Tania Singh ... Diane L Barber
    Clonal naïve human embryonic stem cells assemble an Arp2/3 complex-dependent contractile actin filament ring around colonies that promotes tensional forces favoring cell-cell adhesion and nuclear translocation of YAP to maintain ground-state pluripotency.
    1. Developmental Biology
    2. Neuroscience

    Synapse weakening-induced caspase-3 activity confers specificity to microglia-mediated synapse elimination

    Zhou Yu, Andrian Gutu ... Erin K O’Shea
    Not revised
    Reviewed Preprint v1
    • Important
    • Incomplete
    1. Cancer Biology
    2. Computational and Systems Biology

    Robust estimation of cancer and immune cell-type proportions from bulk tumor ATAC-Seq data

    Aurélie Anne-Gaëlle Gabriel, Julien Racle ... David Gfeller
    EPIC-ATAC accurately quantifies cell-type heterogeneity in tumor bulk ATAC-Seq samples using reliable cell-type specific chromatin accessibility markers for the major cell types found in tumor microenvironments.
    1. Genetics and Genomics

    Identifying in vivo genetic dependencies of melanocyte and melanoma development

    Sarah Perlee, Yilun Ma ... Richard M White
    Not revised
    Reviewed Preprint v1
    • Important
    • Convincing
    1. Chromosomes and Gene Expression

    An anciently diverged family of RNA binding proteins maintain correct splicing of a class of ultra-long exons through cryptic splice site repression

    Chileleko Siachisumo, Sara Luzzi ... David J Elliott
    A family of RNA binding proteins that diverged 200 million years ago have parallel roles in protecting the transcriptomic integrity of ultra-long exons within their respective cell types.
    1. Cell Biology

    A Ctnnb1 enhancer transcriptionally regulates Wnt signaling dosage to balance homeostasis and tumorigenesis of intestinal epithelia

    Xiaojiao Hua, Chen Zhao ... Yan Zhou
    An enhancer-dependent transcriptional machinery finely tunes the expression of Ctnnb1 in intestinal crypts, thereby balancing homeostasis and tumorigenesis of intestinal epithelia.
    1. Developmental Biology
    2. Stem Cells and Regenerative Medicine

    Differential growth and transcriptomic profile of stem cell-derived midbrain astrocytes

    Zongze Li, Lucia Fernandez Cardo ... Meng Li
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Solid
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