4,580 results found
    1. Evolutionary Biology
    2. Epidemiology and Global Health
    3. Microbiology and Infectious Disease
    4. Genetics and Genomics

    Evolutionary Medicine: A Special Issue

    Edited by George H Perry et al.
    eLife is pleased to present a Special Issue to highlight recent advances in the growing and increasingly interdisciplinary field of evolutionary medicine.
    1. Physics of Living Systems

    Epithelial colonies in vitro elongate through collective effects

    Jordi Comelles et al.
    Spontaneous elongation of epithelial colonies is related to the orientation of the mean nematic cell elongation field, as shown and tested with experiments and theory.
    1. Immunology and Inflammation

    RNF41 regulates the damage recognition receptor Clec9A and antigen cross-presentation in mouse dendritic cells

    Kirsteen M Tullett et al.
    Dendritic cell recognition and processing of antigens from dead cells, utilising the Clec9A-damage recognition receptor, is controlled by a novel RNF41-ubiquitin-mediated regulatory pathway.
    1. Evolutionary Biology

    Constitutive activation of cellular immunity underlies the evolution of resistance to infection in Drosophila

    Alexandre B Leitão et al.
    Single-cell transcriptomics of immune cells demonstrates that populations evolve inducible defences when infection rates are low and constitutive defences when infection is common.
    1. Neuroscience

    The actin-modulating protein synaptopodin mediates long-term survival of dendritic spines

    Kenrick Yap et al.
    Long-term imaging of dentate granule cells reveals that the presence of synaptopodin within large spines, rather than their size, conveys long-term stability to large spines.
    1. Epidemiology and Global Health

    Time-to-event modeling of hypertension reveals the nonexistence of true controls

    Daniel Shriner et al.
    Despite health disparities among groups, the lifetime risk of hypertension approaches 100% for African Americans, European Americans, and Mexican Americans.
    1. Developmental Biology

    Cytoplasmic sharing through apical membrane remodeling

    Nora G Peterson et al.
    Apical membrane remodeling in a resorptive Drosophila epithelium generates a shared multinuclear cytoplasm.
    1. Cell Biology
    2. Developmental Biology

    Zebrafish Posterior Lateral Line primordium migration requires interactions between a superficial sheath of motile cells and the skin

    Damian E Dalle Nogare et al.
    Epithelial cells utilize a covering sheath of motile cells to migrate in confinement.
    1. Developmental Biology
    2. Physics of Living Systems

    Size-dependent patterns of cell proliferation and migration in freely-expanding epithelia

    Matthew A Heinrich et al.
    Epithelia exhibit size-dependent growth dynamics caused by a decoupling between boundary and bulk cellular dynamics that enable robust expansion and drive cell cycling, collective migration, and tissue-spanning vortices.
    1. Developmental Biology
    2. Neuroscience

    Adrenergic activation modulates the signal from the Reissner fiber to cerebrospinal fluid-contacting neurons during development

    Yasmine Cantaut-Belarif et al.
    The Reissner fiber in the cerebrospinal fluid is required for a signal integrated by developing sensory neurons and modulated by catecholamines to control the embryo posterior axis morphogenesis.

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