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    1. Cell Biology
    2. Genetics and Genomics

    Lipid homeostasis is essential for a maximal ER stress response

    Gilberto Garcia, Hanlin Zhang ... Andrew Dillin
    A genetic screen identifies a lipid pathway which impacts the endoplasmic reticulum unfolded protein response and highlights a mechanism through which lipid disequilibrium might facilitate the progression of proteopathic diseases.
    1. Genetics and Genomics

    Drosophila PDGF/VEGF signaling from muscles to hepatocyte-like cells protects against obesity

    Arpan C Ghosh, Sudhir Gopal Tattikota ... Norbert Perrimon
    A muscle-derived signaling molecule suppresses excessive accumulation of lipids in the Drosophila adipose tissue by activating the Pi3K/Akt/mTOR signaling cascade in the Drosophila hepatocyte-like cells.
    1. Physics of Living Systems
    2. Cell Biology

    Phase transitions of multivalent proteins can promote clustering of membrane receptors

    Sudeep Banjade, Michael K Rosen
    A new and general mechanism describes the organization of membrane proteins and their cytoplasmic ligands into micrometer-scale clusters, based on polymerization and concomitant phase separation of multivalent proteins.
    1. Cell Biology

    TFAP2 transcription factors are regulators of lipid droplet biogenesis

    Cameron C Scott, Stefania Vossio ... Jean Gruenberg
    The biogenesis of lipid droplets induced by Wnt3a is controlled by the transcription factor TFAP2, which presumably acts as a 'master' regulator of lipid droplet biogenesis.
    1. Structural Biology and Molecular Biophysics

    Seipin transmembrane segments critically function in triglyceride nucleation and lipid droplet budding from the membrane

    Siyoung Kim, Jeeyun Chung ... Gregory A Voth
    The functions of seipin in triacylglycerol nucleation and lipid droplet maturation are studied with all-atom and coarse-grained simulations along with cell experiments, providing a novel model for lipid droplet formation.
    1. Cell Biology
    2. Developmental Biology

    The fat body cortical actin network regulates Drosophila inter-organ nutrient trafficking, signaling, and adipose cell size

    Rupali Ugrankar-Banerjee, Son Tran ... W Mike Henne
    Fat-body-specific loss of actin isoform Act5C disrupts fat body cell growth and fat storage, lipoprotein secretion, and insulin signaling, revealing a non-canonical role for the cortical actin cytoskeleton in nutrient signaling and inter-organelle trafficking.
    1. Cell Biology
    2. Developmental Biology

    Imaging cytoplasmic lipid droplets in vivo with fluorescent perilipin 2 and perilipin 3 knock-in zebrafish

    Meredith H Wilson, Stephen C Ekker, Steven A Farber
    Fluorescent perilipin zebrafish lines are powerful new tools for studying lipid droplet dynamics in health and disease.
    1. Cell Biology

    Control of brown adipose tissue adaptation to nutrient stress by the activin receptor ALK7

    Patricia Marmol, Favio Krapacher, Carlos F Ibáñez
    The activin receptor ALK7 regulates the adaptation of brown adipose tissue to nutrient availability by preventing over-activation of signaling pathways induced by fasting, allowing appropriate response to cold exposure.
    1. Ecology

    Adipokinetic hormone signaling mediates the enhanced fecundity of Diaphorina citri infected by ‘Candidatus Liberibacter asiaticus’

    Jiayun Li, Paul Holford ... Xiaoge Nian
    Molecular mechanism that Candidatus Liberibacter asiaticus improves the lipid metabolism and fecundity of Diaphorina citri through adipokinetic hormone and its receptor.
    1. Genetics and Genomics

    Ether lipid biosynthesis promotes lifespan extension and enables diverse pro-longevity paradigms in Caenorhabditis elegans

    Lucydalila Cedillo, Fasih M Ahsan ... Alexander A Soukas
    Increased production of ether lipids is required to extend lifespan in response to metformin, phenformin, and multiple, distinct, longevity-promoting manipulations, illuminating the possibility that raising ether lipid levels represents a new therapeutic strategy to support healthy aging.
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