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Neuronal activity modulates blood–brain barrier permeability, influencing synaptic plasticity and local network reorganization in the healthy brain.

Microtubule streaming driven by molecular motors covers characteristic times that span several orders of magnitude from fast, single-microtubule sliding on molecular scales to slow, collective motion on cellular scales.

Distinct stem cell populations drive larval, somatic, and germline development of the human parasitic flatworm, Schistosoma mansoni.

A combination of mRNA sequencing and genetic analysis reveals mechanisms that govern the development of distinct differentiated blood cell types from hematopoietic progenitors.

Quantitative experiments and theory show that the tension-dependent regulation of NDC80 binding to kinetochore microtubules arises from a combination of the changing Aurora B concentration at NDC80 and the nonlinearity of Aurora B autoactivation.

A key Ras-driven signaling pathway stimulates the preferential translation of an effector, EPSTI1, that is both necessary and sufficient for the epithelial-to-mesenchymal transition-like phenotype in colorectal cancer cells.

Heparan sulfate synthesis by mature oligodendrocytes creates a protective and permissive environment controling microglia and oligodendrocyte progenitors reactivation during remyelination.

New experiments and theory reveal how the ability to see image details depends upon photoreceptor function and eye movements, and how fruit flies (Drosophila) see spatial details beyond the optical limit of their compound eyes.

The inhibitory protein DEPTOR make two widely separated interactions with mTOR that are both necessary for its unique partial mTOR inhibition, and DEPTOR is a more potent inhibitor of mutation- or RHEB-activated mTORC1 than basal mTORC1.