585 results found
    1. Cell Biology
    2. Genetics and Genomics

    Micronuclei-based model system reveals functional consequences of chromothripsis in human cells

    Maja Kneissig et al.
    A method to generate human cells with massive chromosomal aberrations on a specific chromosome allows analysis of their consequences.
    1. Developmental Biology
    2. Human Biology and Medicine

    Prolonged ovarian storage of mature Drosophila oocytes dramatically increases meiotic spindle instability

    Ethan J Greenblatt et al.
    Meiotic chromosome segregation in mature Drosophila oocytes is sensitive to prolonged quiescence, suggesting that human oocyte instability may result from storage of mature rather than primordial oocytes and be modifiable.
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    Movement of accessible plasma membrane cholesterol by the GRAMD1 lipid transfer protein complex

    Tomoki Naito et al.
    GRAMD1 proteins sense a transient expansion of the accessible pool of plasma membrane cholesterol and facilitate its transport to the endoplasmic reticulum at ER-PM contact sites.
    1. Neuroscience

    Agonist-specific voltage-dependent gating of lysosomal two-pore Na+ channels

    Xiaoli Zhang et al.
    Tricyclic antidepressants activate lysosomal two-pore Na+ channels in a voltage-dependent manner.
    1. Cell Biology

    Evolutionarily conserved long-chain Acyl-CoA synthetases regulate membrane composition and fluidity

    Mario Ruiz et al.
    Silencing the acyl-coA synthethase ACSL1 protects against saturated fat lipotoxicity by preventing the degradation of polyunsaturated fatty acids, allowing them to be incorporated into phospholipids and improves membrane fluidity.
    1. Neuroscience

    Single cell transcriptome atlas of the Drosophila larval brain

    Clarisse Brunet Avalos et al.
    Single-cell transcriptomics identifies cellular composition of the first instar Drosophila brain and the response to starvation.
    1. Developmental Biology

    Endothelial EphB4 maintains vascular integrity and transport function in adult heart

    Guillermo Luxán et al.
    EphB4 maintains critical functional properties of the adult cardiac vasculature, namely mechanical resistance and fatty acid transport capability, and thereby prevents dilated cardiomyopathy-like defects.
    1. Neuroscience

    Elevating acetyl-CoA levels reduces aspects of brain aging

    Antonio Currais et al.
    A novel neuroprotective pathway that enhances acetyl-CoA metabolism via inhibition of acetyl-CoA carboxylase 1 may prevent the contribution of the aging process in the brain to Alzheimer's disease.
    1. Developmental Biology
    2. Stem Cells and Regenerative Medicine

    Distinct origins and molecular mechanisms contribute to lymphatic formation during cardiac growth and regeneration

    Dana Gancz et al.
    Cardiac lymphatic vessels of heterogeneous origins and molecular signatures support cardiac growth and regeneration.
    1. Developmental Biology
    2. Human Biology and Medicine

    Induction of Sertoli-like cells from human fibroblasts by NR5A1 and GATA4

    Jianlin Liang et al.
    In vitro reprogramming of human fibroblasts to Sertoli-like cells with immunosuppressive properties provides platforms for basic research and clinical application.

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