Exosomes secreted from pancreatic cancer cells can function as a classic initiator in the multi-step cellular transformation process.

Binding of the second messenger inositol 1,4,5-trisphosphate to its intracellular receptor drives interaction between the intracellular Ca2+ sensor STIM and the plasma membrane localized Ca2+ channel Orai and raises the level of store-operated Ca2+ entry in mammalian cells.

The presynaptic scaffolding protein Bassoon is involved in regulating neurotransmitter release by controlling synaptic vesicle pool size and vesicular protein turnover through increased ubiquitination and Parkin-dependent autophagy.

Hsp47 positively regulates the functional surface expression of endogenous GABA_A receptors and plays a critical and general role in the maturation of Cys-loop neuroreceptors.

A key Ras-driven signaling pathway stimulates the preferential translation of an effector, EPSTI1, that is both necessary and sufficient for the epithelial-to-mesenchymal transition-like phenotype in colorectal cancer cells.

A naturally-occurring small molecule acts as a chemical chaperone in vivo to alter the folding of a budding yeast septin and promote an oligomerization pathway that was lost during evolution.

The evolutionarily conserved polarity protein Crumbs links the regulation of cytoskeleton dynamics and cell-cell adhesion with epithelial morphogenesis.