120 results found
    1. Medicine
    2. Computational and Systems Biology

    Multi-tissue network analysis reveals the effect of JNK inhibition on dietary sucrose-induced metabolic dysfunction in rats

    Hong Yang, Cheng Zhang ... Adil Mardinoglu
    Revised
    Reviewed Preprint v2
    Updated
    • Valuable
    • Solid
    1. Medicine
    2. Neuroscience

    Cold induces brain region-selective cell activity-dependent lipid metabolism

    Hyeonyoung Min, Yale Y Yang, Yunlei Yang
    It is of significance in identifying temperature sensitive brain regions in brain energy metabolism, as which might provide potential targetable sites in the treatment of brain lipid metabolism-associated neurological disorders.
    1. Immunology and Inflammation

    B cell expression of the enzyme PexRAP, an intermediary in ether lipid biosynthesis, promotes antibody responses and germinal center size

    Sung Hoon Cho, Marissa A Jones ... Mark R Boothby
    Not revised
    Reviewed Preprint v1
    • Useful
    • Solid
    1. Immunology and Inflammation

    The protective roles of eugenol on type 1 diabetes mellitus through NRF2-mediated oxidative stress pathway

    Yalan Jiang, Pingping He ... Xiaoou Shan
    Eugenol has the ability to improve the type 1 diabetes mellitus through NRF2-mediated oxidative stress pathway.
    1. Cell Biology
    2. Neuroscience

    Maintenance of neuronal TDP-43 expression requires axonal lysosome transport

    Veronica H Ryan, Sydney Lawton ... Michael E Ward
    Not revised
    Reviewed Preprint v1
    • Important
    • Convincing
    1. Computational and Systems Biology
    2. Cancer Biology

    Decoding Liver Cancer Prognosis: From Multi-omics Subtypes, Prognostic Models to Single Cell Validation

    Yanbin Wang, Yuqi Wu ... Yanmei Zou
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Solid
    1. Epidemiology and Global Health

    Predicting the causal relationship between polyunsaturated fatty acids and cerebral aneurysm risk from a Mendelian randomization study

    Weijie Yu, Liwei Zhou ... Zhanxiang Wang
    Revised
    Reviewed Preprint v2
    Updated
    • Useful
    • Solid
    1. Cell Biology

    Impairment of lipid homeostasis causes lysosomal accumulation of endogenous protein aggregates through ESCRT disruption

    John Yong, Jacqueline E Villalta ... Calvin H Jan
    Genome-wide CRISPRi screens and proteome profiling of lysosomes link lipid dysregulation to ESCRT disruption and proteostasis defect.
    1. Developmental Biology

    The autophagy protein, ATG14 safeguards against unscheduled pyroptosis activation to enable embryo transport during early pregnancy

    Pooja Popli, Arin K Oestreich ... Ramakrishna Kommagani
    Revised
    Reviewed Preprint v2
    Updated
    • Valuable
    • Solid
    1. Cell Biology
    2. Genetics and Genomics

    Multi-species genome-wide CRISPR screens identify conserved suppressors of cold-induced cell death

    Breanna Lam, Kathrin M Kajderowicz ... Sinisa Hrvatin
    Not revised
    Reviewed Preprint v1
    • Important
    • Compelling
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