1,297 results found
    1. Cell Biology

    Niemann-Pick type C proteins promote microautophagy by expanding raft-like membrane domains in the yeast vacuole

    Takuma Tsuji et al.
    Sterol transport by Niemann-Pick type C proteins induces the expansion of raft-like domains in the yeast vacuole, enabling engulfment of lipid droplets by microautophagy.
    1. Structural Biology and Molecular Biophysics

    A lipid bound actin meshwork organizes liquid phase separation in model membranes

    Alf Honigmann et al.
    A combination of imaging experiments and computer simulations on a model lipid membrane integrate the 'picket fence' and 'raft' models, and suggest that the interplay between actin binding, lipid phase separation and curvature compartmentalize the membrane.
    1. Cell Biology
    2. Immunology and Inflammation

    Acute exposure to apolipoprotein A1 inhibits macrophage chemotaxis in vitro and monocyte recruitment in vivo

    Asif J Iqbal et al.
    Mechanistic insights show how treatment with apoA1 is anti-inflammatory by rapidly disrupting macrophage chemotaxis and monocyte recruitment.
    1. Biochemistry and Chemical Biology
    2. Neuroscience

    Mouse TRPA1 function and membrane localization are modulated by direct interactions with cholesterol

    Justyna B Startek et al.
    The activation and membrane localization of the broadly-tuned noxious chemosensory cation channel TRPA1 are regulated by direct interactions with cholesterol via CRAC motifs in transmembane segments 2 and 4.
    1. Developmental Biology

    The glycosphingolipid MacCer promotes synaptic bouton formation in Drosophila by interacting with Wnt

    Yan Huang et al.
    Multiple independent analyses reveal that a specific membrane lipid directly interacts with the signalling protein Wingless to promote synapse growth at the Drosophila neuromuscular junctions.
    1. Developmental Biology

    Requirement of Smurf-mediated endocytosis of Patched1 in sonic hedgehog signal reception

    Shen Yue et al.
    Smurf1 and Smurf2 have essential functions in the mammalian Shh signaling pathway, binding to and ubiquitylating Patched1, leading to its endocytosis and subsequent degradation in lysosomes.
    1. Immunology and Inflammation

    Protein sorting by lipid phase-like domains supports emergent signaling function in B lymphocyte plasma membranes

    Matthew B Stone et al.
    Clustering the B cell receptor generates a membrane domain analogous to the liquid-ordered phase, localizing proteins involved in early receptor activation.
    1. Structural Biology and Molecular Biophysics

    Molecular mechanism of TRPV2 channel modulation by cannabidiol

    Ruth A Pumroy et al.
    Cannabidiol binds to TRPV2 via a previously unidentified, but highly conserved, pocket.
    1. Cell Biology

    Cavin-3 dictates the balance between ERK and Akt signaling

    Victor J Hernandez et al.
    Cavin-3 is a tumor suppressor protein that inhibits Akt signaling, suppresses Warburg metabolism, promotes apoptosis, and protects against cachexia.
    1. Cell Biology

    β3-Adrenoceptor redistribution impairs NO/cGMP/PDE2 signalling in failing cardiomyocytes

    Sophie Schobesberger et al.
    β3-AR signalling via cGMP in cardiomyocytes is regulated via phosphodiesterase 2 and 5 degradation, it is potentially cardioprotective, but dysregulated in heart failure through signal redistribution and higher phosphodiesterase activity.

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