2,430 results found
    1. Cell Biology
    2. Microbiology and Infectious Disease

    Protein-lipid interaction at low pH induces oligomerization of the MakA cytotoxin from Vibrio cholerae

    Aftab Nadeem, Alexandra Berg ... Sun Nyunt Wai
    MakA, a pore-forming cytotoxin produced by Vibrio cholerae, forms oligomers and remodels membranes into high-curvature tubes, resulting in membrane integrity loss inside acidified organelle lumens or when cultured with cells in an acidic medium.
    1. Structural Biology and Molecular Biophysics
    2. Computational and Systems Biology

    Mechanism of allosteric regulation of β2-adrenergic receptor by cholesterol

    Moutusi Manna, Miia Niemelä ... Ilpo Vattulainen
    Atomistic simulations reveal how lipids can allosterically modulate membrane receptors.
    1. Structural Biology and Molecular Biophysics

    Binding mechanism of the matrix domain of HIV-1 gag on lipid membranes

    Viviana Monje-Galvan, Gregory A Voth
    Unbiased molecular dynamics simulations reveal the insertion mechanism of the lipidated tail of the matrix domain of HIV-1 Gag into realistic membrane models and show its effect on lipid sorting.
    1. Structural Biology and Molecular Biophysics
    2. Cell Biology

    The brown adipocyte protein CIDEA promotes lipid droplet fusion via a phosphatidic acid-binding amphipathic helix

    David Barneda, Joan Planas-Iglesias ... Mark Christian
    An interaction between the brown fat protein CIDEA and the phospholipid phosphatidic acid is vital for the expansion of intracellular lipid droplets for energy storage.
    1. Biochemistry and Chemical Biology

    A non-linear system patterns Rab5 GTPase on the membrane

    Alice Cezanne, Janelle Lauer ... Marino Zerial
    Both protein-protein and protein-lipid interactions are essential for Rab5 symmetry breaking at the early endosome.
    1. Structural Biology and Molecular Biophysics
    2. Cell Biology

    Single-molecule force spectroscopy of protein-membrane interactions

    Lu Ma, Yiying Cai ... Yongli Zhang
    A high-resolution method to quantify interactions between lipid bilayers and single proteins under controlled load is presented and applied to key proteins involved in membrane fusion and formation and maintenance of membrane contact sites.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Elucidation of the anti-autophagy mechanism of the Legionella effector RavZ using semisynthetic LC3 proteins

    Aimin Yang, Supansa Pantoom, Yao-Wen Wu
    Legionella effector RavZ evades host autophagy by extracting LC3-PE from the membrane before deconjugation.
    1. Cell Biology
    2. Physics of Living Systems

    A physical mechanism of TANGO1-mediated bulky cargo export

    Ishier Raote, Morgan Chabanon ... Felix Campelo
    TANGO1 functions as a linactant filament to stabilize shallow COPII-coated buds, and after which membrane tension regulation, possibly mediated by TANGO1-controlled membrane fusion, facilitates bud elongation for procollagen export.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Double and triple thermodynamic mutant cycles reveal the basis for specific MsbA-lipid interactions

    Jixing Lyu, Tianqi Zhang ... Arthur Laganowsky
    Native mass spectrometry reveals the thermodynamic basis for high-affinity lipid binding to the ABC transporter MsbA.
    1. Developmental Biology

    The glycosphingolipid MacCer promotes synaptic bouton formation in Drosophila by interacting with Wnt

    Yan Huang, Sheng Huang ... Yong Q Zhang
    Multiple independent analyses reveal that a specific membrane lipid directly interacts with the signalling protein Wingless to promote synapse growth at the Drosophila neuromuscular junctions.

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