64 results found
    1. Cell Biology
    2. Human Biology and Medicine

    Hypoxic mitophagy regulates mitochondrial quality and platelet activation and determines severity of I/R heart injury

    Weilin Zhang et al.
    Mitophagy regulates mitochondrial quality and mediates extensive mitochondrial degradation in (patho-)physiological settings and is one of the key components of hypoxic preconditioning which protects the heart from ischemia/reperfusion injury.
    1. Cell Biology

    Mfn2 ubiquitination by PINK1/parkin gates the p97-dependent release of ER from mitochondria to drive mitophagy

    Gian-Luca McLelland et al.
    A crucial step during the mitophagy cascade involves the disassembly of connections between mitochondria and the endoplasmic reticulum via the retrotranslocation of Mfn2 tethering complexes by the Parkinson's disease genes PARKIN and PINK1, as well as the ATPase VCP/p97.
    1. Cell Biology
    2. Human Biology and Medicine

    Deficiency of parkin and PINK1 impairs age-dependent mitophagy in Drosophila

    Tom Cornelissen et al.
    Mitophagy occurs in Drosophila flight muscle and dopaminergic neurons in vivo and increases with aging in a PINK1/parkin-dependent fashion.
    1. Cell Biology

    Mitochondrial Rab GAPs govern autophagosome biogenesis during mitophagy

    Koji Yamano et al.
    Two GAP proteins bound to mitochondria regulate the enyzme Rab7, and thereby the expansion of the isolation membrane during mitophagy, downstream of PINK1 and Parkin, two proteins that are mutated in familial Parkinson's disease.
    1. Cell Biology

    Endosomal Rab cycles regulate Parkin-mediated mitophagy

    Koji Yamano et al.
    Parkin ubiquitination of damaged mitochondria recruits the Rab GEF, RABGEF1, to regulate downstream Rab cycles and ATG9A recruitment to growing phagophores that are participating in mitophagy.
    1. Cell Biology

    AMPK and vacuole-associated Atg14p orchestrate μ-lipophagy for energy production and long-term survival under glucose starvation

    Arnold Y Seo et al.
    Upon AMPK activation by acute glucose restriction, Atg14p shifts its distribution from ER exit sites to liquid-ordered membrane domains on the vacuolar surface where, together with Atg6p, it facilitates LD-specific autophagy (i.e., microautophagy of lipid droplets) for energy production and long-term survival of starved cells.
    1. Cell Biology

    Elimination of paternal mitochondria in mouse embryos occurs through autophagic degradation dependent on PARKIN and MUL1

    Rebecca Rojansky et al.
    The uniparental inheritance of mammalian mitochondria results from elimination of paternal mitochondria by a mitophagic process that requires the E3 ubiquitin ligases PARKIN and MUL1.
    1. Cell Biology

    Niemann-Pick type C proteins promote microautophagy by expanding raft-like membrane domains in the yeast vacuole

    Takuma Tsuji et al.
    Sterol transport by Niemann-Pick type C proteins induces the expansion of raft-like domains in the yeast vacuole, enabling engulfment of lipid droplets by microautophagy.
    1. Cell Biology

    Mitochondria: Selective protein degradation ensures cellular longevity

    Sandra Malmgren Hill, Thomas Nyström
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    1. Biochemistry and Chemical Biology
    2. Cell Biology

    Proteasome storage granules protect proteasomes from autophagic degradation upon carbon starvation

    Richard S Marshall, Richard D Vierstra
    Proteasomes are protected from autophagic elimination upon carbon starvation by sequestration into cytoplasmic storage granules, which aid cell fitness by providing a cache of proteasomes that can be rapidly remobilized when carbon availability improves.

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