188 results found
    1. Microbiology and Infectious Disease

    Colistin kills bacteria by targeting lipopolysaccharide in the cytoplasmic membrane

    Akshay Sabnis et al.
    Modulation of cytoplasmic lipopolysaccharide levels sensitises bacteria to polymyxin antibiotics, revealing a novel combination therapeutic approach.
    1. Immunology and Inflammation
    2. Microbiology and Infectious Disease

    A model symbiosis reveals a role for sheathed-flagellum rotation in the release of immunogenic lipopolysaccharide

    Caitlin A Brennan et al.
    Both beneficial and pathogenic bacteria can use their sheathed flagella during host colonization as a novel toxin-/signal-delivery mechanism.
    1. Microbiology and Infectious Disease

    A mutant Escherichia coli that attaches peptidoglycan to lipopolysaccharide and displays cell wall on its surface

    Marcin Grabowicz et al.
    A single mutation in Escherichia coli connects two essential cell envelope assembly pathways and confers vancomycin resistance by displaying molecular decoys at the cell surface.
    1. Microbiology and Infectious Disease

    A lipoprotein/β-barrel complex monitors lipopolysaccharide integrity transducing information across the outer membrane

    Anna Konovalova et al.
    Mutations that block assembly of the interlocked RcsF/β barrel protein complex prevent detection of lipopolysaccharide stress and activation of Rcs signal transduction pathway.
    1. Neuroscience

    Gustatory-mediated avoidance of bacterial lipopolysaccharides via TRPA1 activation in Drosophila

    Alessia Soldano et al.
    Fruit flies can taste and avoid food contaminated with a bacterial toxin using the same channel protein that functions in humans as sensor of noxious chemical stimuli.
    1. Microbiology and Infectious Disease
    2. Structural Biology and Molecular Biophysics

    Massive antibody discovery used to probe structure–function relationships of the essential outer membrane protein LptD

    Kelly M Storek et al.
    Dispensable loops shield the functionally-important extracellular loops of the essential Gram-negative bacterial outer membrane protein LptD from antibody interference.
    1. Immunology and Inflammation

    Characterization and functional analysis of cathelicidin-MH, a novel frog-derived peptide with anti-septicemic properties

    Jinwei Chai et al.
    The novel cathelicidin cathelicidin-MH was identified from the skin of M. heymonsivogt frog, which protects against lipopolysaccharide- and cecal ligation and puncture-induced sepsis, effectively ameliorates multi-organ pathology, especially in lung.
    1. Neuroscience

    One bout of neonatal inflammation impairs adult respiratory motor plasticity in male and female rats

    Austin D Hocker et al.
    A single neonatal inflammatory event induces long-term impairments in two forms of adult respiratory motor plasticity, an important aspect of the control of breathing for compensation after injury or disease.
    1. Microbiology and Infectious Disease

    Defining the function of OmpA in the Rcs stress response

    Kilian Dekoninck et al.
    In vivo and in vitro approaches uncover a new function for the β-barrel OmpA and reveal how it interacts with the stress sensor lipoprotein RcsF.
    1. Immunology and Inflammation

    A novel pathway of LPS uptake through syndecan-1 leading to pyroptotic cell death

    Shigetoshi Yokoyama et al.
    A novel pathway was discovered for cellular uptake of LPS through secretory protein secretoglobin3A2 and a receptor syndecan-1, causing activation of non-canonical inflammasome pathway leading to pyroptosis of cancer cells.

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