In-lab evolution of synthetic promoters has revealed a novel general mechanism for de novo evolution of gene regulation, and highlights the crucial role of expression noise in this process.
An experimentally constrained multiscale mathematical model predicts that branched actin networks self-organize at endocytic sites and bend to produce force, which was verified with cryo-electron tomography of intact cells.
Nicholas W Frankel, William Pontius ... Thierry Emonet
An experimentally constrained model shows that Escherichia coli faces fitness trade-offs in chemotaxis behaviors, and that adaptation of phenotypic diversity through altered gene regulation permits populations to resolve these trade-offs.
Qinyu Hao, Minxue Liu ... Kannanganattu V Prasanth
A novel family of nucleolus-enriched ncRNAs forms allele-specific territories on the nucleolar organizing region (NOR)-containing acrocentric chromosomes.
Secretion and fibrillogenesis of collagen-I are separately controlled molecular pathways in the fibroblast, where surprisingly endocytic recycling is required for fibril formation and is increased in fibrotic fibroblasts.
