141 results found
    1. Human Biology and Medicine
    2. Microbiology and Infectious Disease

    Mechanisms of virus dissemination in bone marrow of HIV-1–infected humanized BLT mice

    Mark S Ladinsky et al.
    Large-volume light microscopy combined with higher-resolution electron tomography revealed the spatial distribution of virus-producing cells and highlighted mechanisms of HIV-1 dissemination in bone marrow from a small animal model.
    1. Genetics and Genomics
    2. Immunology and Inflammation

    SCGN deficiency results in colitis susceptibility

    Luis F Sifuentes-Dominguez et al.
    A novel mutation in SCGN is associated with risk for inflammatory bowel disease and implicates the intestinal neuroendocrine compartment in the pathogenesis of this disorder.
    1. Neuroscience

    Differential contributions of the two human cerebral hemispheres to action timing

    Anja Pflug et al.
    Brain imaging reveals frequency-dependent lateralized rhythmic finger tapping control by the auditory cortex with left-lateralized control of relative fast and right-lateralized control of relative slow rhythms.
    1. Cell Biology

    β-blockers augment L-type Ca2+ channel activity by targeting spatially restricted β2AR signaling in neurons

    Ao Shen et al.
    FRET biosensor-based measurement of cAMP signaling and single-channel recording reveal that β-blockers trigger local activation of adrenergic receptors and calcium channels in primary neurons.
    1. Epidemiology and Global Health
    2. Human Biology and Medicine

    Discovery proteomics in aging human skeletal muscle finds change in spliceosome, immunity, proteostasis and mitochondria

    Ceereena Ubaida-Mohien et al.
    The changes in the skeletal muscle proteome with age indicate the roots of the decline in muscle function with age.
    1. Neuroscience

    Olfactory connectivity mediates sleep-dependent food choices in humans

    Surabhi Bhutani et al.
    Sleep deprivation enhances energy-dense food choices and encoding of olfactory information in the human brain.
    1. Human Biology and Medicine
    2. Stem Cells and Regenerative Medicine

    Merging organoid and organ-on-a-chip technology to generate complex multi-layer tissue models in a human retina-on-a-chip platform

    Kevin Achberger et al.
    A microphysiological system (retina-on-a-chip) shows the potential to promote drug development and provide new insights into the underlying pathology of retinal diseases.
    1. Plant Biology

    Anion channel SLAH3 is a regulatory target of chitin receptor-associated kinase PBL27 in microbial stomatal closure

    Yi Liu et al.
    S-type anion channel activity, which promotes stomatal closure and improves anti-fungal immunity in plants, is directly regulated through phosphorylation by a kinase of the chitin receptor complex.
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    Hemozoin produced by mammals confers heme tolerance

    Rini H Pek et al.
    Heme accumulation is toxic, but deficiency of the heme transporter HRG1/SLC48A1 causes heme sequestration and crystallization into hemozoin within enlarged lysosomes of macrophages, thereby conferring heme tolerance to mammals.

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