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A biophysical model in which kinetochore microtubules nucleate at kinetochores and growth polward along nematic streamlines quantitatively explains kinetochore microtubule lengths, orientations, and spatially varying dynamics in metaphase human spindles.

Simulations of the biological function of an antifreeze protein reveal its molecular interactions with the ice/water interface.

Many small-molecule fragments bind differently to the allosteric protein PTP1B in room-temperature instead of cryogenic crystal structures, which may be relevant for structure-based drug design.

The disease-associated aggregation of polyglutamine begins in a single molecule with a specific structure.

Protein crystallization is a rare event yet Ym1 crystals made from a chitinase-like protein are abundantly found in eosinophilic airway inflammation, where they promote type 2 immunity.

The utilization of hydrogen/deuterium exchange mass spectrometry reveals dynamic insights and interactions driving liquid-liquid demixing of the chromosome passenger complex.

The complete architecture of human spliceosomal U1 snRNP and its interaction with the 5′ splice site of pre-mRNA are described in atomic detail.

A novel strategy for reproducible cryo-EM sample preparation with minimal sample volumes.

Sodium ions but not protons induce defined helix movements in a sodium/proton antiporter and suggest a mechanism for Na + binding and transport.

Porcelaneous foraminifera, marine calcifiers, reveal their biomineralization secrets.